Evidence map›Paper›PMID 40076840›Full record

ArticleInternational journal of molecular sciences2025

Beneficial Antioxidant Effects of Coenzyme Q10 in In Vitro and In Vivo Models of CDKL5 Deficiency Disorder.

Manuela Loi, Francesca Valenti, Giorgio Medici, Nicola Mottolese, Giulia Candini, Angelica Marina Bove, Federica Trebbi, Luca Pincigher, Romana Fato, Christian Bergamini and 2 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Multicellular senescence programs in the aged heart.Journal of molecular and cellular cardiology plus · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Manuela LoiDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Piazza di Porta San Donato 2, 40126 Bologna, Italy.ORCID 0000-0002-6179-7610
Francesca ValentiDepartment of Pharmacy and Biotechnology, University of Bologna, Via Irnerio 42, 40126 Bologna, Italy.ORCID 0000-0002-7266-7352
Giorgio MediciDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Piazza di Porta San Donato 2, 40126 Bologna, Italy.
Nicola MottoleseDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Piazza di Porta San Donato 2, 40126 Bologna, Italy.ORCID 0000-0002-3066-0945
Giulia CandiniDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Piazza di Porta San Donato 2, 40126 Bologna, Italy.ORCID 0009-0005-5029-9594
Angelica Marina BoveDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Piazza di Porta San Donato 2, 40126 Bologna, Italy.
Federica TrebbiDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Piazza di Porta San Donato 2, 40126 Bologna, Italy.
Luca PincigherDepartment of Pharmacy and Biotechnology, University of Bologna, Via Irnerio 42, 40126 Bologna, Italy.ORCID 0009-0002-9806-2789
Romana FatoDepartment of Pharmacy and Biotechnology, University of Bologna, Via Irnerio 42, 40126 Bologna, Italy.ORCID 0000-0002-8945-6826
Christian BergaminiDepartment of Pharmacy and Biotechnology, University of Bologna, Via Irnerio 42, 40126 Bologna, Italy.ORCID 0000-0003-4387-5117
Stefania TrazziDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Piazza di Porta San Donato 2, 40126 Bologna, Italy.ORCID 0000-0003-2623-2769
Elisabetta CianiDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Piazza di Porta San Donato 2, 40126 Bologna, Italy.ORCID 0000-0003-3130-5168

Funding

Italian parent association "CDKL5 insieme verso la cura" Ciani 2024Ministero dell'università e della ricerca Mission 4 Component 2, Investment 3.3 (DM 352/2022 and DM 117/2023)Ministero dell'università e della ricerca National Recovery and Resilience Plan (NRRP), project MNESYS (PE0000006; DN. 1553 11.10.2022)
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AntioxidantsEpileptic SyndromesMuscle WeaknessProtein Serine-Threonine KinasesSpasms, InfantileUbiquinoneAnimalsCell ProliferationDisease Models, AnimalDNA DamageFemaleFibroblastsGlutathioneHumansMiceOxidative StressAntioxidantscoenzyme Q10GlutathioneProtein Serine-Threonine KinasesReactive Oxygen SpeciesUbiquinoneCDKL5 deficiency disordercoenzyme Q10mouse modeloxidative stress

Identifiers

PMID40076840
PMCPMC11900000

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.