ReviewInternational journal of molecular sciences2025
Vitamin D in Reproductive Health Disorders: A Narrative Review Focusing on Infertility, Endometriosis, and Polycystic Ovarian Syndrome.
Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Association Between Serum Vitamin D Levels and Insulin Resistance in Women With Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis.The journal of obstetrics and gynaecology research · 2026Pooled it
- The Association Between Vitamin D and Polycystic Ovary Syndrome (PCOS) in Women: A Systematic Review.Nutrients · 2026Pooled it
- Therapeutic Effects of Vitamins in Endometriosis Patients: A Systematic Review of Randomized Controlled Trials.International journal of molecular sciences · 2026Pooled it
- Influence of vitamin D supplementation on ovarian reserve as reflected by anti-Müllerian hormone levels: a meta-analysis of randomized controlled trials.Frontiers in endocrinology · 2026Pooled it
- Review
- Vitamin D as a Modulator of Sarcopenia in Women: Interactions with Dietary Patterns and Physical Exercise.Nutrients · 2026Review
- Vitamin D Status and Reproductive Hormonal Profiles in Early Versus Physiological Menopause: A Comparative Observational Study.Biomedicines · 2026Article
- Dyslipidemias associated with endocrine disorders: a position statement of the working group of the nutrition hormones and metabolism club of the italian society of endocrinology (SIE).Journal of endocrinological investigation · 2026Article
- Effect of vitamin D deficiency on pregnancy outcomes in obese and non-obese pregnant women.BMC pregnancy and childbirth · 2026Article
- Review
- Effects of Age, Season, and Pregnancy History on Vitamin D Status in Women Seeking Preconception Care.Medical science monitor : international medical journal of experimental and clinical research · 2026Article
- Seasonal and geographic patterns of gastroschisis in Canada: protective effect of periconceptional sunlight exposure.Frontiers in endocrinology · 2026Article
- Micronutrients in polycystic ovary syndrome: molecular pathways, deficiencies, and therapeutic potential.Frontiers in endocrinology · 2026Review
- Vitamin D in Endocrine Disorders: A Broad Overview of Evidence in Musculoskeletal, Thyroid, Parathyroid, and Reproductive Disorders.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Reducing Storage-Related Bias in Reproductive Vitamin D Research: Towards a Stable and Reliable Biomarker of Ovarian Vitamin D Status.Nutrients · 2025Article
- Increased Vitamin D Receptor Immunoreactivity in Endometrial Polyps: An Exploratory Single-Center Pilot Study.Cureus · 2025Article
- Cholecalciferol (vitamin D3): efficacy, safety, and implications in public health.Frontiers in nutrition · 2025Review
- Endocrine roles of vitamin D in female reproduction: Mechanisms and clinical implications.Women's health (London, England)Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vitamin D (VD) is a fat-soluble steroid hormone with essential physiological functions beyond calcium and bone metabolism. In recent years, its role in women's reproductive health has gained attention, influencing ovarian function, follicular development, endometrial receptivity, and steroid hormone regulation. VD deficiency has been linked to reproductive disorders such as polycystic ovarian syndrome (PCOS), endometriosis, and infertility. Studies indicate that up to 40-50% of healthy pregnant women have insufficient VD levels, which may contribute to adverse pregnancy outcomes and reduced fertility. With growing evidence connecting VD to reproductive health, this review examines its molecular and endocrine mechanisms in fertility, endometriosis, and PCOS. It explores VD's therapeutic potential and its implications for improving clinical approaches and future research in reproductive medicine. Maintaining adequate VD levels is crucial for ovarian function, immune modulation in reproductive tissues, and overall fertility. Its deficiency is associated with insulin resistance, hormonal imbalances, and inflammatory processes, which contribute to reproductive pathophysiology. Establishing reference values for VD in reproductive medicine is essential for optimizing fertility treatments and improving clinical outcomes. This review synthesizes current research on VD's role in reproductive health and highlights the need for further investigation into its therapeutic applications.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.