ArticleInternational journal of molecular sciences2025
Differential Myocardial Responses in Male and Female Rats with Uremic Cardiomyopathy.
Beáta Bódi, Rebeka Rita Vágó, László Nagy, Arnold Péter Ráduly, András Gulyás, Klaudia Kupecz, Lilian Azar, Fanni Magdolna Márványkövi, Gergő Szűcs, Andrea Siska and 4 more
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In one paragraphArticle in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
14 authors.
Beáta BódiDivision of Clinical Physiology, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.
Rebeka Rita VágóDivision of Clinical Physiology, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.
László NagyDivision of Clinical Physiology, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.
Arnold Péter RádulyDivision of Clinical Physiology, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.ORCID 0000-0003-0616-8405 András GulyásDepartment of Pathophysiology, Albert Szent-Györgyi Medical School, University of Szeged, H-6720 Szeged, Hungary.
Klaudia KupeczDepartment of Pathophysiology, Albert Szent-Györgyi Medical School, University of Szeged, H-6720 Szeged, Hungary.
Lilian AzarDepartment of Pathophysiology, Albert Szent-Györgyi Medical School, University of Szeged, H-6720 Szeged, Hungary.ORCID 0009-0004-3395-9274 Fanni Magdolna MárványköviDepartment of Biochemistry, Interdisciplinary Center of Excellence, Albert Szent-Györgyi Medical School, University of Szeged, H-6720 Szeged, Hungary.
Gergő SzűcsDepartment of Biochemistry, Interdisciplinary Center of Excellence, Albert Szent-Györgyi Medical School, University of Szeged, H-6720 Szeged, Hungary.ORCID 0000-0003-1874-2718 Andrea SiskaDepartment of Laboratory Medicine, Albert Szent-Györgyi Medical School, University of Szeged, H-6720 Szeged, Hungary.ORCID 0000-0002-2252-7095 Gábor CserniDepartment of Pathology, Albert Szent-Györgyi Medical School, University of Szeged, H-6720 Szeged, Hungary.
Imre FöldesiDepartment of Laboratory Medicine, Albert Szent-Györgyi Medical School, University of Szeged, H-6720 Szeged, Hungary.
Zoltán PappDivision of Clinical Physiology, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.ORCID 0000-0002-4675-1542 Márta SárközyDepartment of Pathophysiology, Albert Szent-Györgyi Medical School, University of Szeged, H-6720 Szeged, Hungary.ORCID 0000-0002-5929-2146 Funding
National Research, Development and Innovation Fund of the Ministry of Innovation and Technology (Hungary) EFOP-3.6.2-16-2017-00006 (LIVE LONGER)National Research, Development and Innovation Fund of the Ministry of Innovation and Technology (Hungary) GINOP-2.3.2-15-2016-00040National Research, Development and Innovation Fund of the Ministry of Innovation and Technology (Hungary) NKFIH FK129094
6 · The paper itselfAbstract
Uremic cardiomyopathy, characterized by diastolic dysfunction, left ventricular hypertrophy (LVH), and fibrosis, is a common cardiovascular complication of chronic kidney disease (CKD). Men are at a higher risk for cardiovascular and renal diseases, compared to age-matched, pre-menopausal women. We aimed to investigate the influence of sex on the severity of uremic cardiomyopathy through the characterization of functional and molecular indices of myocardial remodeling in a rat model. CKD was induced by a 5/6 nephrectomy in 9-week-old male and female Wistar rats. Serum and urine tests, transthoracic echocardiography, left ventricular (LV) histology, and quantitative reverse transcription polymerase chain reaction (RT-qPCR) were performed at week 8 or 9. Moreover, LV alterations were also tested in permeabilized cardiomyocytes (CMs) by force measurements and Western immunoblotting. CKD resulted in the development of a more severe uremic cardiomyopathy in male rats-including LVH, LV diastolic dysfunction, and fibrosis-than in female rats, where only LVH was observed. A uremic cardiomyopathy was also associated with a decrease in maximal Ca
Indexed as
CardiomyopathiesMyocardiumRenal Insufficiency, ChronicUremiaAnimalsDisease Models, AnimalEchocardiographyFemaleFibrosisHypertrophy, Left VentricularMaleMyocytes, CardiacRatsRats, WistarSex FactorsVentricular Remodelingactive forcediastolic dysfunctionleft ventricular hypertrophypassive stiffnesspermeabilized cardiomyocyteuremic cardiomyopathy
Identifiers
PMID40076880
PMCPMC11900185
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