SynthesisNutrients2025
Effectiveness of Herbal Medicines with Anti-Inflammatory, Antimicrobial, and Antioxidant Properties in Improving Oral Health and Treating Gingivitis and Periodontitis: A Systematic Review.
Synthesis in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- Effects of Xipayi Gingival Solution combined with minocycline hydrochloride on inflammatory cytokines and masticatory function in patients with chronic periodontitis.Frontiers in cellular and infection microbiology · 2026Trial
- Microbiological and Clinical Short-Term Evaluation of the Efficacy of an Herbal Tincture as an Adjunctive Treatment in the Management of Stage II, Grade A Periodontitis.Pathogens (Basel, Switzerland) · 2025Trial
- UHPLC-DAD-QToF-MS profiling and marker compound analysis ofRSC advances · 2026Article
- Biomimetic and Locally Active Drug Delivery Systems for the Oral Biofilm and Periodontal Pocket: Formulation Strategies, Mechanisms and Translational Perspectives.Pharmaceutics · 2026Review
- Review
- Review
- Breast Cancer: Epidemiology, Molecular Classification, Diagnostics and Evolving Treatment Paradigms.Molecules (Basel, Switzerland) · 2026Review
- Integrative Analysis of Triphala's Therapeutic Mechanisms in Periodontitis: Network Pharmacology-guided Investigation with Experimental Validation in Cellular and Animal Models.Oral health & preventive dentistry · 2026Article
- Comparative Clinical Evaluation of Chamomile, Sage, and Ginger Mouthwashes in Reducing Plaque and Gingival Inflammation.Antibiotics (Basel, Switzerland) · 2026Article
- Natural Bioactive Compounds in Dental Materials: Balancing Biological Activity and Functional Properties.Pharmaceutics · 2026Review
- Probiotics and Ozonated Olive Oil to Maintain Oral Eubiosis in Stage I and II Periodontitis Patients: A Randomized Triple-Blind Clinical Trial.Dentistry journal · 2026Article
- Traditional Foods, Oral Microbiome, and Systemic Health: Molecular Pathways Linking Nutrition and Oral Disease Prevention.International journal of molecular sciences · 2026Review
- Implant Surface Characteristics and Peri-Implant Outcomes: A Systematic Review of Clinical and Microbiological Evidence.Bioengineering (Basel, Switzerland) · 2026Review
- Review
- Topical Polyherbal Phytopreparation Reduces Gingival Inflammation: Evidence from a Randomized Controlled Clinical Study Supported by In Silico Analysis.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Plant-based treatment modalities for peri-implant diseases: a scoping review.BMC complementary medicine and therapies · 2026Article
- Adjunctive Therapies in Periodontitis: Current Concepts and the Future.Journal of periodontal research · 2026Review
- Non-Thermal Plasma vs. Low-Level Laser Therapy for Recurrent Oral Ulcers: A Randomized Controlled Pilot Study.Biomedicines · 2026Article
- A scientometric study on the characteristics of herbal medicine and identification of herbaceous agents for treatment of periodontal diseases.Journal of dental sciences · 2026Article
- Natural supplements in breast cancer therapy: translational evidence, clinical safety, and emerging challenges.Frontiers in oncology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis systematic review investigates the effectiveness of natural extracts with anti-inflammatory properties for improving oral health, particularly in managing gingivitis and periodontal disease (PD). With PD being a major global health issue, exacerbated by microbial dysbiosis and oxidative stress, the integration of phytochemicals and herbal formulations into periodontal therapy offers a promising avenue for adjunctive treatments.
methodsA systematic review was conducted following PRISMA guidelines and registered under the International Prospective Register of Systematic Reviews (ID: 641944). Databases, including PubMed, Scopus, and Web of Science, were searched between 18-24 December 2024, using Boolean keywords combining terms such as "herbal medicine", "plant extracts", "anti-inflammatory", and "periodontal therapy". Studies involving animal models, in vitro data, or non-peer-reviewed articles were excluded.
resultsSeventeen studies met inclusion criteria. Polyherbal formulations and single-component extracts (e.g.,
conclusionsNatural products, including single extracts and polyherbal formulations, provide effective and safe alternatives for managing gingivitis and PD. Their anti-inflammatory, antimicrobial, and antioxidant properties support their adjunctive role alongside with scaling and root planning therapy (SRP) in periodontal therapy. However, further large-scale, long-term studies are needed to standardize formulations and establish optimal protocols.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.