Evidence map›Paper›PMID 40077793›Full record

ArticleNutrients2025

Milk Exosome-Based Delivery System for Probiotic Encapsulation That Enhances the Gastrointestinal Resistance and Adhesion of Probiotics.

Linlin Hao, Yinxue Liu, Ignatius Man-Yau Szeto, Haining Hao, Tai Zhang, Tongjie Liu, Huaxi Yi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Linlin HaoCollege of Food Science and Engineering, Ocean University of China, Qingdao 266003, China.
Yinxue LiuCollege of Food Science and Engineering, Ocean University of China, Qingdao 266003, China.
Ignatius Man-Yau SzetoInner Mongolia Yili Industrial Group Co., Ltd., National Center of Technology Innovation for Dairy, Hohhot 010000, China.
Haining HaoCollege of Food Science and Engineering, Ocean University of China, Qingdao 266003, China.
Tai ZhangCollege of Food Science and Engineering, Ocean University of China, Qingdao 266003, China.
Tongjie LiuCollege of Food Science and Engineering, Ocean University of China, Qingdao 266003, China.
Huaxi YiCollege of Food Science and Engineering, Ocean University of China, Qingdao 266003, China.ORCID 0000-0002-8968-4263

Funding

National Center of Technology Innovation for Dairy No.2023-KFKT-7
6 · The paper itself

Abstract

The oral administration of probiotics is a promising strategy to regulate the host-intestinal flora balance and improve health. Nevertheless, adverse gastrointestinal (GI) conditions affect the activity of free native probiotics. In this study, a novel probiotic encapsulation system based on milk exosomes (mExos) and DSPE-PEG-PBA was developed. mExos acted as a shield to protect probiotics from harsh GI environments, and DSPE-PEG-PBA served as a bridge between mExos and probiotics. The coated probiotics were characterized by transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FT-IR), and intrinsic fluorescence spectra. The results showed three probiotics (

Indexed as

Bacterial AdhesionDrug Delivery SystemsExosomesGastrointestinal MicrobiomeGastrointestinal TractMilkProbioticsAkkermansiaAnimalsBifidobacterium animalisBile Acids and SaltsDrug CompoundingHumansHydrogen-Ion ConcentrationPolyethylene GlycolsVerrucomicrobiaBile Acids and SaltsPolyethylene Glycolscell adhesionencapsulationmilk exosomesprobioticsresistance

Identifiers

PMID40077793
PMCPMC11902061

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.