Evidence map›Paper›PMID 40078103›Full record

Trial reportJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2025

Cognitive behavioral therapy for insomnia is associated with reduced sleep apnea severity but not its endotype traits in those with comorbid insomnia and sleep apnea.

Elliot J Brooker, Shane A Landry, Pedro R Genta, Gabriel T Abdelmessih, Bradley A Edwards, Sean P A Drummond

Abstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. The ventilatory response to arousal from sleep is elevated in young individuals with post-traumatic stress disorder symptoms.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026
    Article
  4. Article
  5. Expanded benefits of cognitive behavioral therapy for insomnia in people with comorbid insomnia and sleep apnea.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Elliot J BrookerSchool of Psychological Sciences, Monash University, Clayton, Victoria, Australia.
Shane A LandryBiomedicine Discovery Institute, Department of Physiology, Monash University, Clayton, Victoria, Australia.
Pedro R GentaFaculdade de Medicina, Unidade de Disturbios do Sono, Divisão de Pneumologia, Instituto do Coração (InCor), Hospital das Clínicas HCFMUSP, Universidade de São Paulo, São Paulo, Brasil.
Gabriel T AbdelmessihSchool of Psychological Sciences, Monash University, Clayton, Victoria, Australia.
Bradley A EdwardsSchool of Psychological Sciences, Monash University, Clayton, Victoria, Australia.
Sean P A DrummondSchool of Psychological Sciences, Monash University, Clayton, Victoria, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

STUDY

objectivesCognitive behavioral therapy for insomnia (CBT-I) improves obstructive sleep apnea (OSA) severity in comorbid insomnia and sleep apnea, though the mechanisms underlying this change are unstudied. CBT-I, which promotes sleep continuity and reduces hyperarousal, may improve OSA by raising the respiratory arousal threshold. We aimed to investigate the effect of CBT-I on OSA severity and its impact on the arousal threshold and other endotype traits.

methodsIn this single-arm trial, 25 patients with comorbid insomnia and sleep apnea (13 females and 12 males, mean age [standard deviation] = 53.7 [8.7] years) completed a 7-week individual CBT-I program. Patients met diagnostic criteria for insomnia and demonstrated an apnea-hypopnea index (AHI) ≥ 10 events/h (mean AHI [standard deviation]

resultsThere was a 7.7 ± 10.2 events/h reduction in the AHI from baseline to posttreatment (

conclusionsCBT-I is beneficial in improving insomnia symptoms and we provide further support CBT-I improves OSA severity. Despite no change in the OSA endotype traits, the improvement in the AHI may be associated with increased amounts of stage N3 sleep. These results underscore the importance of managing insomnia in comorbid insomnia and sleep apnea. CLINICAL

trial registrationRegistry: Australian New Zealand Clinical Trial Registry; Name: Project COMISA (Comorbid Insomnia and obstructive Sleep Apnea): A study investigating the effect of cognitive behavioral therapy for insomnia (CBT-I) on obstructive sleep apnea severity and cognitive functioning in patients experiencing COMISA; URL: http://www.anzctr.org.au/; Identifier: ACTRN12622000226707. CITATION: Brooker EJ, Landry SA, Genta PR, Abdelmessih GT, Edwards BA, Drummond SPA. Cognitive behavioral therapy for insomnia is associated with reduced sleep apnea severity but not its endotype traits in those with comorbid insomnia and sleep apnea.

Indexed as

Cognitive Behavioral TherapySleep Apnea, ObstructiveSleep Apnea SyndromesSleep Initiation and Maintenance DisordersAdultComorbidityFemaleHumansMaleMiddle AgedPolysomnographySeverity of Illness IndexTreatment OutcomeCBT-Icognitive behavioral therapy for insomniaCOMISAcomorbid insomnia and sleep apneaendotypeinsomniaobstructive sleep apneapathophysiology

Identifiers

PMID40078103
PMCPMC12134586

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.