Evidence map›Paper›PMID 40079340›Full record

ArticleJournal of the American Heart Association2025

Correlating Left Atrial Enlargement and Left Ventricular Hypertrophy on ECG With Echocardiography and Cardiac Magnetic Resonance Imaging.

Max M Puthenpura, Joseph Sipko, Parvathy R Sankar, Cassandra Garraud, Animesh Tandon, Justin Lee, Ajay Bhargava, Venu Menon, Deborah Kwon, Mina K Chung and 1 more

Abstract read
In one paragraph

Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Max M PuthenpuraDepartment of Vascular Medicine Cleveland Clinic Cleveland OH USA.ORCID 0000-0002-3821-1095
Joseph SipkoDepartment of Internal Medicine Cleveland Clinic Cleveland OH USA.ORCID 0009-0008-3990-7407
Parvathy R SankarDepartment of Cardiology, Heart and Vascular Center Beaumont Hospital Royal Oak MI USA.ORCID 0009-0002-8340-5478
Cassandra GarraudDepartment of Cardiovascular Medicine Heart Vascular & Thoracic Institute, Cleveland Clinic Cleveland OH USA.
Animesh TandonDepartment of Pediatrics Cleveland Clinic Lerner College of Medicine of Case Western Reserve University Cleveland OH USA.ORCID 0000-0001-9769-8801
Justin LeeDepartment of Cardiovascular Medicine Heart Vascular & Thoracic Institute, Cleveland Clinic Cleveland OH USA.ORCID 0000-0003-2823-9243
Ajay BhargavaDepartment of Cardiovascular Medicine Heart Vascular & Thoracic Institute, Cleveland Clinic Cleveland OH USA.
Venu MenonDepartment of Cardiovascular Medicine Heart Vascular & Thoracic Institute, Cleveland Clinic Cleveland OH USA.ORCID 0000-0003-4410-2677
Deborah KwonDepartment of Cardiovascular Medicine Heart Vascular & Thoracic Institute, Cleveland Clinic Cleveland OH USA.ORCID 0000-0003-2191-4111
Mina K ChungDepartment of Cardiovascular Medicine Heart Vascular & Thoracic Institute, Cleveland Clinic Cleveland OH USA.ORCID 0000-0002-7835-6045
Heba S WassifDepartment of Cardiovascular Medicine Heart Vascular & Thoracic Institute, Cleveland Clinic Cleveland OH USA.ORCID 0000-0001-6398-8106

Funding

Improving Phenotypic Classification and Prediction of Treatment Outcomes in Patients with Non-ischemic Cardiomyopathy and Functional Mitral RegurgitationR01HL170090 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI DEBORAH KWON · 2023 to 2026
$3.1M
Novel Cardiac MRI-Based Predictors for Tetralogy of Fallot: Deformation, Kinematic, and Geometric AnalysesK23HL150279 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI TANDON, ANIMESH · 2021 to 2025
$847k
NHLBI NIH HHS K23 HL150279NHLBI NIH HHS R01 HL170090
6 · The paper itself

Abstract

backgroundECGs are a primary assessment of cardiac structure and function. Alignment of their findings with cardiac imaging is not well defined. This study investigates the correlation of left atrial enlargement and left ventricular hypertrophy (LVH) found on ECG with transthoracic echocardiogram and cardiac magnetic resonance imaging (CMR) findings.

methodsThis is a single-center retrospective study of 1000 patients. It included patients with positive ECG criteria for left atrial enlargement or left ventricular hypertrophy (LVH) with transthoracic echocardiograms done within the same month. CMR data were included if within 6 months of the ECG. Receiver operator curves and area under the curves (AUC) were calculated based on whether ECG findings were confirmed on either imaging.

resultsLeft atrial enlargement ECG criteria best correlating with transthoracic echocardiograms were p-wave duration of 120+ ms in lead II (AUC, 0.81 [95% CI, 0.79-0.83];

conclusionsECG criteria for left atrial enlargement and LVH correlated poorly with both transthoracic echocardiograms and CMR. Updating current waveform criteria may improve diagnostic accuracy of ECGs.

Indexed as

EchocardiographyElectrocardiographyHeart AtriaHypertrophy, Left VentricularMagnetic Resonance Imaging, CineAgedFemaleHumansMaleMiddle AgedPredictive Value of TestsRetrospective Studiescardiac MRIECGechocardiographyleft atrial enlargement (LAE)left ventricular hypertrophy (LVH)

Identifiers

PMID40079340
PMCPMC12132768

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.