Evidence map›Paper›PMID 40079555›Full record

ArticleJournal of hypertension2025

Haemodynamic changes from prepregnancy to very early pregnancy among women planning to conceive in Southwestern Uganda.

Henry M Lugobe, Carmel M Mceniery, Musa Kayondo, Janet M Catov, Joseph Ngonzi, Charles Batte, Bonnie Wandera, Bruce Kirenga, Blair J Wylie, Adeline A Boatin and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of hypertension, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Comparison of the associations between office and home BP with placenta-mediated pregnancy complications: the BOSHI study.Hypertension research : official journal of the Japanese Society of Hypertension · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Henry M LugobeDepartment of Obstetrics and Gynecology, Mbarara University of Science and Technology, Mbarara, Uganda.
Carmel M McenieryDivision of Experimental medicine, University of Cambridge, Cambridge, UK.
Musa KayondoDepartment of Obstetrics and Gynecology, Mbarara University of Science and Technology, Mbarara, Uganda.
Janet M CatovDepartment of Obstetrics, Gynecology and Reproductive Sciences, School of Medicine, University of Pittsburgh, Magee-Women's Research Institute, Pittsburgh, Pennsylvania, USA.
Joseph NgonziDepartment of Obstetrics and Gynecology, Mbarara University of Science and Technology, Mbarara, Uganda.
Charles BatteLung Institute, Makerere University College of Health Sciences, Kampala, Uganda.
Bonnie WanderaLung Institute, Makerere University College of Health Sciences, Kampala, Uganda.
Bruce KirengaLung Institute, Makerere University College of Health Sciences, Kampala, Uganda.
Blair J WylieDepartment of Obstetrics and Gynecology, Columbia University Medical Center, New York USA.
Adeline A BoatinDepartment of Obstetrics and Gynecology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Kwame Adu-BonsaffohDepartment of Obstetrics and Gynecology, University of Ghana medical school, Accra, Ghana.
David C AgabaDepartment of Physiology, Mbarara University of Science and Technology, Mbarara.
Ian B WilkinsonDivision of Experimental medicine, University of Cambridge, Cambridge, UK.

Funding

Training in noncommunicable diseases epidemiological, data science and Implementation Science research to strengthen evidence-based interventions, policy and control in Uganda.D43TW011401 · FIC · MAKERERE UNIVERSITY COLLEGE OF HEALTH SCIENCES · PI Charles Batte, William Checkley · 2019 to 2026
$1.8M
FIC NIH HHS D43 TW011401
6 · The paper itself

Abstract

introductionNormal pregnancy is associated with cardiovascular changes that enable adaptation to the pregnancy state. We sought to describe the haemodynamic changes from prepregnancy to very early pregnancy in women planning to conceive in southwestern Uganda.

methodsIn this prospective cohort study, we enrolled women in southwestern Uganda planning to conceive. Brachial and central blood pressure, heart rate, cardiac output, stroke volume, and peripheral vascular resistance were assessed prepregnancy and repeated in very early pregnancy.

resultsWe studied 86 women with a mean age of 27.8 years (SD ± 4.4). The mean gestational age was 7 (±2) weeks at the time of repeat blood pressure measurement. Brachial systolic and diastolic blood pressure decreased in very early pregnancy (116 ± 11 to 114 ± 8 mmHg and 68 ± 6 to 65 ± 5 mmHg, respectively; P  < 0.001). Central systolic and diastolic blood pressure also decreased (112 ± 10 to 109 ± 8 mmHg, P  = 0.003 and 68 ± 6 to 65 ± 5 mmHg, P  < 0.001, respectively), as did peripheral vascular resistance (1450 ± 581 to 1311 ± 276 dyn/s/cm 5P  = 0.038). There was no significant difference in cardiac output (5.3 ± 1.2 vs 5.5 ± 1.1 l/min P  = 0.146) or stroke volume (64 ± 13 to 66 ± 12 ml, P  = 0.172).

conclusionSignificant haemodynamic changes occur in very early pregnancy. Using late first trimester measurements as a baseline for pregnancy induced changes may not be suitable for understanding the full extent of pregnancy induced haemodynamic changes, or provide a reliable substitute for prepregnancy states.

Indexed as

HemodynamicsAdultBlood PressureCardiac OutputFemaleHeart RateHumansPregnancyProspective StudiesUgandaVascular ResistanceYoung Adult

Identifiers

PMID40079555
PMCPMC11964837

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.