ArticleBrain and behavior2025
Abnormal Functional Network Centrality and Causal Connectivity in Migraine Without Aura: A Resting-State fMRI Study.
Article in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The 200 most influential publications in migraine research: a bibliometric mapping of the intellectual landscape.Frontiers in neurology · 2025Pooled it
- Two-sample Mendelian randomization study of gut microbiota and inflammatory proteins: Predictive, preventive, and personalized treatment for migraine.Neural regeneration research · 2026Article
- Subtype-specific enhancement of implicit statistical learning in migraine: insights from BOLD signal variability.The journal of headache and pain · 2026Article
- Altered network homogeneity of the default mode network in patients with tension-type headache.Frontiers in neurology · 2026Article
- Increased integration and synergy in EEG- and fNIRS-based data in migraine patients after a three-month treatment with galcanezumab: relations with long-term clinical outcome.Scientific reports · 2025Article
- Association between white matter microstructural and functional abnormalities and clinical characteristics in migraine without aura: a mediation analysis.Frontiers in neurology · 2025Article
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Authors and funding
8 authors.
Funding
Abstract
objectiveThe pathophysiological mechanism of migraine is still not clear. Thus, this study aimed to evaluate the changes in effective connectivity (EC) in the brain functional network underlying migraine and its association with clinical measures of migraine.
backgroundFifty patients with episodic migraine without aura (MwoA) and 48 healthy controls (HCs) were enrolled in this study. Spontaneous activity in the brain was evaluated using the degree centrality (DC) method, and the brain regions with obvious signal differences between the two groups were taken as seed points for whole brain Granger causality analysis (GCA) analysis. The values of the brain regions with differences in DC and GCA were extracted and correlated with clinical measures of migraine.
resultsCompared to the HCs, the MwoA patients showed decreased DC in the left inferior temporal gyrus (ITG) and increased DC in the right precuneus and exhibited significantly decreased EC from the left ITG to the left inferior parietal gyrus and right inferior occipital gyrus (IOG) as well as significantly increased EC from the left postcentral gyrus and left cerebellum posterior lobe to the left ITG. Moreover, decreased EC from the left thalamus to the right precuneus was found in the MwoA patients compared to the HCs. The DC values in the right precuneus were significantly negatively correlated with the duration of headache. Additionally, we found a significantly positive correlation between the Migraine Disability Assessment questionnaire score and the EC from the left ITG to the right IOG, as well as between the intensity of headache and the EC from the left thalamus to the right precuneus.
conclusionsThis study found changes in the EC of the brain functional network underlying migraine and their associations with migraine-related parameters. These findings are helpful for understanding the pathophysiological mechanism in migraine patients.
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