Evidence map›Paper›PMID 40079720›Full record

ArticleJournal of acquired immune deficiency syndromes (1999)2025

Identifying preferred program delivery attributes for long-acting injectable cabotegravir-rilpvirine in three U.S. HIV clinics: A discrete choice experiment.

Jose I Gutierrez, Elizabeth T Montgomery, Samantha E Dilworth, Moira C McNulty, Jonathan A Colasanti, Mallory O Johnson, Kimberly A Koester, John A Sauceda, Xavier A Erguera, Kaylin Dance and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of acquired immune deficiency syndromes (1999), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Development of a Layperson Injector Training for the Home-Based Administration of Long-Acting Injectable Antiretroviral Therapies for Persons With HIV.AIDS education and prevention : official publication of the International Society for AIDS Education · 2026
    Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Jose I GutierrezDepartment of Family Health Care Nursing, School of Nursing, University of California San Francisco, San Francisco, California, USA.
Elizabeth T MontgomeryDepartment of Epidemiology and Biostatistics, School of Medicine, University of California San Francisco, San Francisco, California, USA.
Samantha E DilworthCenter for AIDS Prevention Studies, Division of Prevention Science, Department of Medicine, University of California San Francisco, San Francisco, California, USA.
Moira C McNultySection of Infectious Diseases and Global Health, Department of Medicine, University of Chicago, Chicago, Illinois, USA.
Jonathan A ColasantiDivision of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Mallory O JohnsonCenter for AIDS Prevention Studies, Division of Prevention Science, Department of Medicine, University of California San Francisco, San Francisco, California, USA.
Kimberly A KoesterCenter for AIDS Prevention Studies, Division of Prevention Science, Department of Medicine, University of California San Francisco, San Francisco, California, USA.
John A SaucedaCenter for AIDS Prevention Studies, Division of Prevention Science, Department of Medicine, University of California San Francisco, San Francisco, California, USA.
Xavier A ErgueraDivision of HIV, ID and Global Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, USA.
Kaylin DanceDivision of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Manami Diaz TsuzukiSchool of Medicine, University of California San Francisco, San Francisco, California, USA.
Matthew D HickeyDivision of HIV, ID and Global Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, USA.
Andrew D KerkhoffDivision of HIV, ID and Global Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, USA.
Torsten B NeilandsCenter for AIDS Prevention Studies, Division of Prevention Science, Department of Medicine, University of California San Francisco, San Francisco, California, USA.
Ingrid Eshun-WilsonDivision of Infectious Diseases, School of Medicine, Washington University in Saint Louis, Saint Louis, MO, USA.
Elvin GengDivision of Infectious Diseases, School of Medicine, Washington University in Saint Louis, Saint Louis, MO, USA.
Katerina A ChristopoulosDivision of HIV, ID and Global Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, USA.
MODERN ART Study Group

Funding

Understanding Patient, Provider, and Systems Stakeholder Attitudes and Preferences to Optimize Implementation of Long-Acting Injectable Antiretrovirals and Maximize Clinical and Public Health ImpactR01MH123396 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHRISTOPOULOS, KATERINA A, HICKEY, MATTHEW · 2020 to 2023
$3.2M
Mentoring Patient-Oriented Research on Advances to Optimize Engagement in HIV CareK24AI167805 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Katerina A Christopoulos · 2022 to 2026
$963k
NIAID NIH HHS K24 AI167805NIMH NIH HHS R01 MH123396
6 · The paper itself

Abstract

backgroundLong-acting injectable cabotegravir and rilpivirine (CAB/RPV-LA) may overcome adherence barriers and provide treatment choice among people with HIV (PWH). However, little is known about the factors most likely to facilitate CAB/RPV-LA use.

methodsWe conducted a discrete choice experiment (DCE) at three urban U.S. HIV clinics, stratified by care engagement status (sub-optimal care engagement defined as most recent HIV RNA ≥200 copies/mL or <2 primary care visits with no HIV RNA measurement in past year). The DCE had 6 attributes: visit location, conversation with one's HIV provider at injection, extra support services, visit length, extended hours, and cost. We used mixed logit regression to estimate preference weights and latent class analysis to identify preference groupings. We examined associations between covariates, attribute preferences and latent class groups, and estimated shares of preference towards hypothetical scenarios.

resultsBetween December 2021 - May 2022, 370 PWH participated. Median age was 46, 34% were cisgender female/gender minority, 59% African American/Black, 13% Latino/a/x, 34% experienced unstable housing, 19% endorsed illicit substance use, and 27% sub-optimal engagement. Cost and visit location were the most important attributes. Latent class analysis identified three groups: 1) cost-conscious (44%), 2) location-driven (34%), and 3) provider/support services-oriented (22%). Sub-optimally engaged PWH preferred extra support services. Shares of preference suggested a predicted use of CAB/RPV-LA exceeding 80% across delivery scenarios with more preferred features.

conclusionParticipants strongly preferred CAB/RPV-LA delivery at no cost and accessible at their current HIV clinic. Preferences of PWH with sub-optimal engagement were heterogeneous, suggesting the need for tailored, differentiated delivery programs offering choice.

Identifiers

PMID40079720
PMCPMC12445180

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.