Evidence map›Paper›PMID 40079814›Full record

ArticleThe Journal of experimental medicine2025

Enteric tuft cell inflammasome activation drives NKp46+ILC3 IL22 via PGD2 and inhibits Salmonella.

Madeline J Churchill, Ankit Pandeya, Renate Bauer, Tighe Christopher, Stefanie Krug, Roslyn Honodel, Shuchi Smita, Lindsey Warner, Bridget M Mooney, Alexis R Gibson and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of experimental medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Intestinal IL-22RA1 signaling regulatesFrontiers in microbiology · 2025
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Madeline J Churchill *Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR, USA.ORCID 0000-0001-7624-4894
Ankit Pandeya *Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR, USA.ORCID 0000-0002-7433-3129
Renate BauerDepartment of Biosciences and Medical Biology, Paris Lodron University of Salzburg, Salzburg, Austria.ORCID 0009-0009-7109-6656
Tighe ChristopherDepartment of Immunology, University of Washington, Seattle, WA, USA.ORCID 0000-0002-8907-369X
Stefanie KrugDepartment of Microbiology, University of Washington, Seattle, WA, USA.ORCID 0000-0001-6390-3184
Roslyn HonodelDepartment of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR, USA.ORCID 0009-0003-5820-7098
Shuchi SmitaDepartment of Immunology, University of Washington, Seattle, WA, USA.ORCID 0000-0001-8048-9835
Lindsey WarnerDepartment of Immunology, University of Washington, Seattle, WA, USA.ORCID 0000-0002-4258-7271
Bridget M MooneyDepartment of Immunology, University of Washington, Seattle, WA, USA.ORCID 0000-0002-5046-3295
Alexis R GibsonDepartment of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR, USA.ORCID 0000-0003-1078-4841
Patrick S MitchellDepartment of Microbiology, University of Washington, Seattle, WA, USA.ORCID 0000-0001-8375-9060
Elia D Tait WojnoDepartment of Immunology, University of Washington, Seattle, WA, USA.ORCID 0000-0003-2822-296X
Isabella RauchDepartment of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR, USA.ORCID 0000-0003-1897-5693

Funding

Role of the prostaglandin D2 receptor CRTH2 in helminth-induced type 2 inflammation in the intestine.R01AI130379 · NIAID · UNIVERSITY OF WASHINGTON · PI Elia D Tait Wojno · 2017 to 2026
$3.5M
Translation of evolution-guided insights for new models of human infectious diseaseDP2AI154432 · NIAID · UNIVERSITY OF WASHINGTON · PI MITCHELL, PATRICK S · 2021 to 2025
$2.5M
Prostaglandin D2 and its receptor CRTH2 regulate intestinal inflammation and homeostasisR01DK134410 · NIDDK · UNIVERSITY OF WASHINGTON · PI Elia D Tait Wojno · 2023 to 2026
$2.0M
The role of the tuft cell inflammasome in infectionR01AI167974 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI Isabella Rauch · 2022 to 2026
$1.9M
Cystic Fibrosis Foundation SINGH19R0Howard Hughes Medical InstituteNIAID NIH HHS DP2 AI154432NIAID NIH HHS R01 AI130379NIAID NIH HHS R01 AI167974NIDDK NIH HHS R01 DK134410NIH HHS R01 AI130379Oregon Health and Science UniversityRainin FoundationUniversity of Washington
6 · The paper itself

Abstract

To distinguish pathogens from commensals, the intestinal epithelium employs cytosolic innate immune sensors. Activation of the NAIP-NLRC4 inflammasome initiates extrusion of infected intestinal epithelial cells (IEC) upon cytosolic bacterial sensing. We previously reported that activation of the inflammasome in tuft cells, which are primarily known for their role in parasitic infections, leads to the release of prostaglandin D2 (PGD2). We observe that NAIP-NLRC4 inflammasome activation in tuft cells leads to an antibacterial response with increased IL-22 and antimicrobial protein levels within the small intestine, which is dependent on PGD2 signaling. A NKp46+ subset of ILC3 expresses the PGD2 receptor CRTH2 and is the source of the increased IL-22. Inflammasome activation in tuft cells also leads to better control of Salmonella Typhimurium in the distal small intestine. However, tuft cells in the cecum and colon are dispensable for antibacterial immunity. These data support that intestinal tuft cells can also induce antibacterial responses, possibly in a tissue-specific manner.

Indexed as

Antigens, LyInflammasomesInterleukinsNatural Cytotoxicity Triggering Receptor 1Prostaglandin D2Salmonella typhimuriumAnimalsInterleukin-22Intestinal MucosaMiceMice, Inbred C57BLReceptors, ImmunologicReceptors, ProstaglandinSignal TransductionTuft CellsAntigens, LyInflammasomesInterleukin-22InterleukinsNatural Cytotoxicity Triggering Receptor 1Ncr1 protein, mouseProstaglandin D2prostaglandin D2 receptorReceptors, ImmunologicReceptors, Prostaglandin

Identifiers

PMID40079814
PMCPMC11905811

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.