Evidence map›Paper›PMID 40080108›Full record

SynthesisAIDS (London, England)2025

Effect of HIV on respiratory symptoms, health status, and exertional capacity.

Ioannis Konstantinidis, Spyridon N Papageorgiou, Richard H Zou, Andreas Ronit, M Bradley Drummond, Ken M Kunisaki, Kristina Crothers, S Mehdi Nouraie, Alison Morris

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in AIDS (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ioannis KonstantinidisDivision of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, University of Pittsburgh.
Spyridon N PapageorgiouClinic of Orthodontics and Pediatric Dentistry, Center for Dental Medicine, University of Zurich, Zurich, Switzerland.
Richard H ZouDivision of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, University of Pittsburgh.
Andreas RonitDepartment of Infectious Diseases, Copenhagen University Hospital - Amager and Hvidovre Hospitals, Hvidovre, Denmark.
M Bradley DrummondDivision of Pulmonary Diseases and Critical Care Medicine, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Ken M KunisakiSection of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Minneapolis Veterans Affairs Healthcare System, Minneapolis, MN.
Kristina CrothersVeterans Affairs Puget Sound Healthcare System and Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Washington, Seattle, WA, USA.
S Mehdi NouraieDivision of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, University of Pittsburgh.
Alison MorrisDivision of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, University of Pittsburgh.

Funding

Pittsburgh HIV Mentored Training for Investigation of Co-morbidities and Cure (HIV MeTrICC)K12HL143886 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MELLORS, JOHN W, MORRIS, ALISON · 2018 to 2022
$1.7M
Risk factors for chronic obstructive pulmonary disease exacerbations, quality of care, and outcomes in people with HIVK08HL169023 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Ioannis Konstantinidis · 2023 to 2026
$653k
NHLBI NIH HHS K08 HL169023NHLBI NIH HHS K12 HL143886
6 · The paper itself

Abstract

objectivePeople with HIV (PWH) have increased risk for worse pulmonary function and increased emphysema. HIV has been proposed as a risk factor for respiratory patient-reported outcomes (PROs). We assessed the association of HIV with respiratory symptoms, respiratory health status, and functional exercise capacity.

designSystematic review and meta-analysis.

methodsWe searched PubMed, EMBASE, CENTRAL, CDSR, WoS, Scopus, CINAHL, and GIM through November 2023 for studies of PWH and people without HIV (PWOH) reporting respiratory PROs. Primary outcomes were activity-limiting dyspnea (defined as Modified Medical Research Council Dyspnea Scale score ≥2), respiratory health status by St. George's Respiratory Questionnaire (SGRQ), and exertional capacity by 6-min walking distance (6MWD). We performed random-effects meta-analyses estimating odds ratios (ORs) and mean differences with 95% confidence intervals (CIs).

resultsWe included 89 publications corresponding to 56 studies. HIV was associated with activity-limiting dyspnea (OR 1.67; 95% CI 1.05-2.65), worse respiratory health status (SGRQ mean difference 2.9 units; 95% CI 0.6-5.2), worse exertional capacity (6MWD mean difference -58.9 m; 95% CI -115.3 to -2.4), and chronic cough, dyspnea, phlegm, and wheeze (OR 1.38-1.78). Respiratory symptom and adverse respiratory health status risk was greatest in European PWH. Certainty of evidence was very low, primarily due to studies' observational design and inconsistency.

conclusionPWH have increased risk for worse respiratory PROs. Systematic respiratory PRO assessment should be incorporated into routine clinical care to facilitate active case-finding of chronic lung disease in PWH. Future studies should longitudinally co-assess objective physiologic measures and respiratory PROs.

Indexed as

Exercise ToleranceHealth StatusHIV InfectionsDyspneaHumansPatient Reported Outcome Measuresexercise testHIV infectionslung diseasesobstructivepatient outcome assessmentquality of liferespiratorysigns and symptoms

Identifiers

PMID40080108
PMCPMC12202180

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.