Evidence map›Paper›PMID 40080432›Full record

ArticleAnalytical chemistry2025

RASER for Increased Spectral Resolution in Carbon-13 NMR.

Christopher Nelson, Andreas B Schmidt, Isaiah Adelabu, Shiraz Nantogma, Seth Dilday, Nicholas Volya, Iuliia Mandzhieva, Valerij G Kiselev, Abubakar Abdurraheem, Henri de Maissin and 4 more

Abstract read
In one paragraph

Article in Analytical chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Quantum magnetic J-oscillators.Nature communications · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Christopher NelsonDepartment of Chemistry, North Carolina State University, Raleigh, North Carolina 27695-8204, United States.
Andreas B SchmidtDivision of Medical Physics, Department of Radiology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Killianstr. 5a, Freiburg 79106, Germany.ORCID 0000-0001-8944-7463
Isaiah AdelabuDepartment of Chemistry, Integrative Biosciences (Ibio), Karmanos Cancer Institute (KCI), Wayne State University, Detroit, Michigan 48202, United States.ORCID 0000-0002-9475-0851
Shiraz NantogmaDepartment of Chemistry, Integrative Biosciences (Ibio), Karmanos Cancer Institute (KCI), Wayne State University, Detroit, Michigan 48202, United States.
Seth DildayDepartment of Chemistry, North Carolina State University, Raleigh, North Carolina 27695-8204, United States.
Nicholas VolyaDepartment of Chemistry, North Carolina State University, Raleigh, North Carolina 27695-8204, United States.
Iuliia MandzhievaDepartment of Chemistry, North Carolina State University, Raleigh, North Carolina 27695-8204, United States.ORCID 0000-0001-9154-9012
Valerij G KiselevGerman Cancer Consortium (DKTK), Partner Site Freiburg and German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Abubakar AbdurraheemDepartment of Chemistry, Integrative Biosciences (Ibio), Karmanos Cancer Institute (KCI), Wayne State University, Detroit, Michigan 48202, United States.
Henri de MaissinDivision of Medical Physics, Department of Radiology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Killianstr. 5a, Freiburg 79106, Germany.
Sören LehmkuhlInstitute of Microstructure Technology, Karlsruhe Institute of Technology Eggenstein-Leopoldshafen, Karlsruhe, 76344, Germany.ORCID 0000-0002-1321-7677
Stephan AppeltInstitute of Technical and Macromolecular Chemistry, RWTH Aachen University, Aachen 52056, Germany.
Eduard Y ChekmenevDepartment of Chemistry, Integrative Biosciences (Ibio), Karmanos Cancer Institute (KCI), Wayne State University, Detroit, Michigan 48202, United States.ORCID 0000-0002-8745-8801
Thomas TheisDepartment of Chemistry, North Carolina State University, Raleigh, North Carolina 27695-8204, United States.ORCID 0000-0001-6779-9978

Funding

Plug-and-play Hyperpolarized MRI of Metabolism on Clinical ScannersR01EB034197 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI Eduard Chekmenev, Matthew Scot Rosen · 2024 to 2026
$1.8M
Molecular MRI of Brain Metabolism Enabled by Long-Lived Spin StatesR01EB029829 · NIBIB · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI THEIS, THOMAS · 2020 to 2020
$807k
Molecular imaging with a hyperpolarized Vitamin ShotR21EB025313 · NIBIB · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI THEIS, THOMAS · 2018 to 2019
$661k
NIBIB NIH HHS R01 EB029829NIBIB NIH HHS R01 EB034197NIBIB NIH HHS R21 EB025313
6 · The paper itself

Abstract

Precision in nuclear magnetic resonance (NMR) spectroscopy and resolution in magnetic resonance imaging (MRI) are thought to be fundamentally limited by the transverse relaxation time. With the recent advent of radiofrequency amplification by stimulated emission of radiation (RASER), it is becoming apparent that RASERs can break these fundamental limitations and provide significant improvements in the resolution of NMR spectra and the resolution in MRI images. In this article, we show that carbon-13 RASERs can be controlled by changes to the magnetic field homogeneity and the spin coupling network. As illustrative examples of tools commonly employed in high-resolution NMR spectroscopy, we employ the control of magnetic field homogeneity with simple changes to the sample geometry and the spin-coupling network with proton decoupling pulses. These changes control the distance of the NMR system from the RASER threshold. Finally, we demonstrate that the

Identifiers

PMID40080432
PMCPMC12702417

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.