ArticleScience (New York, N.Y.)2025
Tunneling nanotube-like structures regulate distant cellular interactions during heart formation.
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Article in Science (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22citing papers in PubMed
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Who cites it
22 citing papers in PubMed.
- Tunneling nanotubes contribute to Zika virus pathogenesis at the maternal-fetal interfacemBio · 2026Article
- Regulation and function of specialized membrane protrusions in intercellular communication.Nature reviews. Molecular cell biology · 2026Review
- Article
- Tunnelling Nanotube-Mediated Lysosome Sharing Promotes Osteocyte Survival via Transcellular Autophagy.Cell proliferation · 2026Article
- Tunneling nanotubes: a new dimension of intercellular communication and recent progress.Cell communication and signaling : CCS · 2026Review
- From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer.FEBS open bio · 2026Review
- The molecular architecture of tunneling nanotubes.bioRxiv : the preprint server for biology · 2026Article
- 3D bioprinting of microfluidic systems for cardiac regenerative medicine: from biofabrication to organ-on-a-chip.Journal of biological engineering · 2026Review
- Building the bridges: molecular mechanisms of tunneling nanotube formation.Cellular and molecular life sciences : CMLS · 2026Review
- Mitochondrial Transfer: From Bench to Bedside.Circulation research · 2026Review
- PGC-derived migrasomes couple PGC proliferation with migration.Nature communications · 2026Article
- Breaking cellular boundaries: molecular mechanisms of tunneling nanotube formation and fusion.Biochemical Society transactions · 2026Review
- Cytoskeletal remodeling promotes tunneling nanotube formation and drives cardiac resident cell mitochondrial transfer in sepsis.Science advances · 2026Article
- Mobile Powerhouses: Mitochondria Transfer via Tunnelling Nanotubes in Brain Health and Neurodegenerative Diseases.The European journal of neuroscience · 2026Review
- Transmitophagy in the heart: An overview of molecular mechanisms and implications for pathophysiology.Acta pharmaceutica Sinica. B · 2026Review
- Intercellular highways of viral spread: tunneling nanotubes and extracellular vesicles at the maternal-fetal interface.Current opinion in virology · 2025Review
- Cell Fate Determination and Lineage Tracing: Technological Evolution and Multidimensional Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Mechanisms of Mitochondrial Transfer Through TNTs: From Organelle Dynamics to Cellular Crosstalk.International journal of molecular sciences · 2025Review
- Tunnelling nanotube-like structures facilitate cell-cell communication during heart development.Nature reviews. Cardiology · 2025Article
- Notch signaling pathway and heart development, congenital heart disease, and myocardial regeneration.Frontiers in bioengineering and biotechnology · 2025Review
Corrections and comments
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Authors and funding
22 authors.
Lianjie MiaoPharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX, USA.ORCID 0000-0002-8286-9783
Yangyang LuPharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX, USA.
Anika NusratPharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX, USA.ORCID 0000-0001-6570-5106
Guizhen FanDepartment of Biochemistry and Molecular Biology, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID 0000-0002-6741-6989
Shaohua ZhangNew Cornerstone Investigator Institute, State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.ORCID 0000-0002-7300-4091
Luqi ZhaoPharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX, USA.ORCID 0009-0005-7914-0018
Chia-Ling WuPharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX, USA.
Hongyan GuoPharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX, USA.ORCID 0009-0005-8863-3236
Trang Le Nu HuyenPharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX, USA.ORCID 0009-0009-6121-0398
Yi ZhengDivision of Experimental Hematology and Cancer Biology, Children's Hospital Medical Center, University of Cincinnati, 3333 Brunet Avenue, Cincinnati, OH, USA.ORCID 0000-0001-7089-6074
Zhen-Chuan FanDepartment of Obstetrics and Gynecology, Center for Reproductive Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China.ORCID 0000-0003-1712-3413
Weinian ShouHerman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA.ORCID 0000-0001-5538-9605
Robert J SchwartzBiology and Biochemistry, University of Houston, Houston, TX, USA.ORCID 0000-0001-9202-2984
Yu LiuBiology and Biochemistry, University of Houston, Houston, TX, USA.
Ashok KumarPharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX, USA.ORCID 0000-0001-8571-2848
Haixin SuiDivision of Translational Medicine, Wadsworth Center, New York State Department of Health, Albany, NY, USA.ORCID 0000-0002-5560-4325
Irina I SeryshevaDepartment of Biochemistry and Molecular Biology, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID 0000-0001-6266-3422
Alan R BurnsCollege of Optometry, University of Houston, Houston, TX, USA.ORCID 0000-0001-9293-3104
Leo Q WanDepartments of Biomedical Engineering and Biological Sciences, Rensselaer Polytechnic Institute, Troy, NY, USA.ORCID 0000-0001-8371-5623
Bin ZhouNew Cornerstone Investigator Institute, State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.ORCID 0000-0001-5278-5522
Sylvia M EvansSkaggs School of Pharmacy and Pharmaceutical Sciences, Department of Pharmacology, School of Medicine, University of California San Diego, La Jolla, CA, USA.
Mingfu WuPharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX, USA.ORCID 0000-0003-0155-2328
Funding
Research Programming ModuleP30EY007551 · NEI · UNIVERSITY OF HOUSTON · PI LAURA J. FRISHMAN · 1988 to 2026
$16.4MSignaling by beta 1 integrins regulates ventricular wall morphogenesis and compactionR01HL121700 · NHLBI · UNIVERSITY OF HOUSTON · PI Mingfu Wu, YANG Kevin XIANG · 2015 to 2026
$5.4MStructure-Function Studies Of IP3R ChannelsR01GM072804 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI SERYSHEVA, IRINA I · 2005 to 2023
$4.8MTWEAK/Fn14/UPR Signaling in Skeletal Muscle WastingR01AR081487 · NIAMS · UNIVERSITY OF HOUSTON · PI ASHOK KUMAR · 2023 to 2026
$2.1MACQUISITION OF HIGH-THROUGHPUT 200 kV CRYO-TEMS10OD032204 · OD · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI SERYSHEVA, IRINA I · 2022 to 2022
$2.0MMechanisms of signaling interaction between endocardium and myocardiumR01HL172834 · NHLBI · UNIVERSITY OF HOUSTON · PI Mingfu Wu · 2024 to 2026
$2.0MMechanisms of inositol trisphosphate receptor-mediated calcium signalingR35GM153178 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Irina I Serysheva · 2024 to 2026
$1.7MIntraflagellar transport process in primary cilium maintenanceR01GM143223 · NIGMS · WADSWORTH CENTER · PI SUI, HAIXIN · 2021 to 2024
$1.5MStructural basis of ER-mitochondria membrane contacts and neuronal healthR21NS138590 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI SERYSHEVA, IRINA I · 2024 to 2024
$429kDefining architecture of EC coupling machinery in situR21AR082833 · NIAMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI SERYSHEVA, IRINA I · 2023 to 2024
$372kAmerican Heart Association-American Stroke Association 23CDA1048883American Heart Association-American Stroke Association 25EIA1422015NEI NIH HHS P30 EY007551NHLBI NIH HHS R01 HL121700NHLBI NIH HHS R01 HL172834NIAMS NIH HHS R01 AR081487NIAMS NIH HHS R21 AR082833NIGMS NIH HHS R01 GM072804NIGMS NIH HHS R01 GM143223NIGMS NIH HHS R35 GM153178NIH HHS S10 OD032204NINDS NIH HHS R21 NS138590
Abstract
In the developing mammalian heart, the endocardium and the myocardium are separated by so-called cardiac jelly. Communication between the endocardium and the myocardium is essential for cardiac morphogenesis. How membrane-localized receptors and ligands achieve interaction across the cardiac jelly is not understood. Working in developing mouse cardiac morphogenesis models, we used a variety of cellular, imaging, and genetic approaches to elucidate this question. We found that myocardium and endocardium interacted directly through microstructures termed tunneling nanotube-like structures (TNTLs). TNTLs extended from cardiomyocytes (CMs) to contact endocardial cells (ECs) directly. TNTLs transported cytoplasmic proteins, transduced signals between CMs and ECs, and initiated myocardial growth toward the heart lumen to form ventricular trabeculae-like structures. Loss of TNTLs disturbed signaling interactions and, subsequently, ventricular patterning.
Indexed as
Cell CommunicationEndocardiumHeartMyocardiumMyocytes, CardiacOrganogenesisAnimalsEndothelial CellsFemaleMaleMiceNanotubesSignal Transduction
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.