Evidence map›Paper›PMID 40081849›Full record

ArticleAJNR. American journal of neuroradiology2025

Dissociation of Structural and Functional Connectivity and Metabolism in the Neocortex of Idiopathic Generalized Epilepsy: A Simultaneous PET/MRI Multimodal Study.

Chenyang Yao, Jie Hu, Bixiao Cui, Jingjuan Wang, Zhen-Ming Wang, Yaqin Hou, Kharel Sudeep, Hongwei Yang, Yihe Wang, Yongzhi Shan and 1 more

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In one paragraph

Article in AJNR. American journal of neuroradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Chenyang YaoFrom the Department of Radiology and Nuclear Medicine (C.Y., J.H., J.W., B.C., Z.-M.W., Y.H., K.S., H.Y., J.L.), Xuanwu Hospital Capital Medical University, Beijing, China.
Jie HuFrom the Department of Radiology and Nuclear Medicine (C.Y., J.H., J.W., B.C., Z.-M.W., Y.H., K.S., H.Y., J.L.), Xuanwu Hospital Capital Medical University, Beijing, China.
Bixiao CuiFrom the Department of Radiology and Nuclear Medicine (C.Y., J.H., J.W., B.C., Z.-M.W., Y.H., K.S., H.Y., J.L.), Xuanwu Hospital Capital Medical University, Beijing, China.ORCID https://orcid.org/0000-0003-4353-4590
Jingjuan WangFrom the Department of Radiology and Nuclear Medicine (C.Y., J.H., J.W., B.C., Z.-M.W., Y.H., K.S., H.Y., J.L.), Xuanwu Hospital Capital Medical University, Beijing, China.ORCID https://orcid.org/0000-0002-3224-0880
Zhen-Ming WangFrom the Department of Radiology and Nuclear Medicine (C.Y., J.H., J.W., B.C., Z.-M.W., Y.H., K.S., H.Y., J.L.), Xuanwu Hospital Capital Medical University, Beijing, China.
Yaqin HouFrom the Department of Radiology and Nuclear Medicine (C.Y., J.H., J.W., B.C., Z.-M.W., Y.H., K.S., H.Y., J.L.), Xuanwu Hospital Capital Medical University, Beijing, China.ORCID https://orcid.org/0000-0002-0194-1174
Kharel SudeepFrom the Department of Radiology and Nuclear Medicine (C.Y., J.H., J.W., B.C., Z.-M.W., Y.H., K.S., H.Y., J.L.), Xuanwu Hospital Capital Medical University, Beijing, China.
Hongwei YangFrom the Department of Radiology and Nuclear Medicine (C.Y., J.H., J.W., B.C., Z.-M.W., Y.H., K.S., H.Y., J.L.), Xuanwu Hospital Capital Medical University, Beijing, China.ORCID https://orcid.org/0000-0003-1042-247X
Yihe WangDepartment of Neurosurgery (Y.W., Y.S.), Xuanwu Hospital Capital Medical University, Beijing, China.
Yongzhi ShanDepartment of Neurosurgery (Y.W., Y.S.), Xuanwu Hospital Capital Medical University, Beijing, China.
Jie LuFrom the Department of Radiology and Nuclear Medicine (C.Y., J.H., J.W., B.C., Z.-M.W., Y.H., K.S., H.Y., J.L.), Xuanwu Hospital Capital Medical University, Beijing, China imaginglu@hotmail.com.ORCID https://orcid.org/0000-0003-0425-3921

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeIdiopathic generalized epilepsy (IGE) accounts for approximately 20% of epilepsy cases. Characterized by generalized spike-wave discharge, IGE is increasingly recognized as a network disorder with potential metabolic underpinnings. This study leverages the advantages of simultaneous PET/MRI, which enables the concurrent acquisition of MRI and PET data, to integrate structural connectivity (SC), functional connectivity (FC), and glucose metabolism into a unified framework. This study aims to elucidate the multimodal abnormalities of the neocortex in IGE, to analyze the correlations between these abnormalities and clinical presentations, and to investigate the interactions among different imaging modalities. MATERIALS AND

methodsTwenty-one patients with IGE and 34 healthy controls (HCs) were recruited. Simultaneous PET/MRI scans were performed, incorporating DTI, resting-state fMRI, and [

resultsSC abnormalities were primarily found in the limbic (40% of all abnormal neocortical regions) and visual networks (31%), while FC abnormalities were mostly in the default mode network (DMN, 45%). Metabolic abnormalities were predominantly in the frontoparietal (26%) and somatomotor (22%) networks. SC in the limbic was positively correlated with onset age, while seizure frequency was negative correlated with DMN FC and positively correlated with frontoparietal metabolism. Mediation analysis showed that DMN FC mediated the relationship between limbic SC and frontoparietal and somatomotor metabolism.

conclusionsA multimodal approach reveals distinct and interrelated abnormalities in IGE, with different modalities reflecting various aspects of the disease, thus enhancing our understanding of its complex mechanisms. This integrative analysis could inform more effective treatments.

Indexed as

Epilepsy, GeneralizedMagnetic Resonance ImagingMultimodal ImagingNeocortexPositron-Emission TomographyAdolescentAdultFemaleFluorodeoxyglucose F18HumansMaleMiddle AgedYoung AdultFluorodeoxyglucose F18

Identifiers

PMID40081849
PMCPMC12152784

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.