Evidence map›Paper›PMID 40082802›Full record

ArticleBMC neurology2025

Association of cardiometabolic index and new-onset stroke in middle-aged and elderly Chinese: a national prospective cohort study.

Yibo Yang, ZhenKun Xiao, Jing Teng, Hailong Zhong, Yonghong Duan, Min Zhou, Bing Wang, Aihua Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Observational
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yibo Yang *Department of Neurosurgery, Hengyang Medical School, The Second Affiliated Hospital, University of South China, Hengyang, Hunan, 421001, China.
ZhenKun Xiao *Department of Neurosurgery, Hengyang Medical School, The Second Affiliated Hospital, University of South China, Hengyang, Hunan, 421001, China.
Jing TengInstitute of Cardiovascular Disease, Hengyang Medical School, The First Affiliated Hospital, University of South China, Hengyang, Hunan, 421001, China.
Hailong ZhongInstitute of Cardiovascular Disease, Hengyang Medical School, The First Affiliated Hospital, University of South China, Hengyang, Hunan, 421001, China.
Yonghong DuanDepartment of Neurosurgery, Hengyang Medical School, The Second Affiliated Hospital, University of South China, Hengyang, Hunan, 421001, China.
Min ZhouDepartment of Neurosurgery, Hengyang Medical School, The Second Affiliated Hospital, University of South China, Hengyang, Hunan, 421001, China.
Bing WangDepartment of Neurosurgery, Hengyang Medical School, The Second Affiliated Hospital, University of South China, Hengyang, Hunan, 421001, China. wangbing@usc.edu.cn.
Aihua LiuDepartment of Neurosurgery, Hengyang Medical School, The Second Affiliated Hospital, University of South China, Hengyang, Hunan, 421001, China. 16673498449@163.com.

Funding

Beijing Municipal Administration of Hospitals' Ascent Plan DFL20190501Beijing Natural Science Foundation 19L2013; 22G10396BTH Coordinated Development-Beijing Science and Technology Planning Project Z181100009618035Nanhua University 4310 Project 20214310NHYPY03National Clinical Key Specialty Major Scientific Research Project 20230279Natural Science Foundation of China 81771233, 82171290Research and Promotion Program of Appropriate Techniques for Intervention of Chinese High-risk Stroke People GN-2020R0007
6 · The paper itself

Abstract

BACKGROUND AND

aimsThe Cardiometabolic Index (CMI), a novel metabolic marker, has been associated with various metabolic diseases in previous studies. However, its relationship with stroke risk remains underexplored. This study investigates the potential correlation between CMI and stroke risk among Chinese adults aged 45 and older.

methodsIn the China Health and Retirement Longitudinal Study (CHARLS), participants were categorized into four groups based on CMI quartiles. The primary outcome was the incidence of new strokes during the follow-up period. A Cox proportional hazards model was used to analyze the relationship between CMI and stroke risk among the elderly. Kaplan-Meier survival analysis compared incidence rates across CMI levels, and restricted cubic splines (RCS) assessed potential non-linear relationships between CMI and stroke. Subgroup analyses verified the robustness of these findings.

resultsThe study included 6620 patients (45% male), with 417 new stroke cases reported over an average follow-up of seven years. Multivariate analysis indicated a significant association between increased CMI and higher stroke risk [HR, 1.132 (1.021-1.273), P = 0.003]. The RCS model revealed a nonlinear increase in stroke risk with rising CMI levels (P for nonlinearity = 0.006). No significant interactions were detected between CMI and the selected subgroups (all P values for interaction > 0.05).

conclusionCMI significantly correlates with stroke risk in the elderly Chinese population, suggesting its potential utility in early risk stratification.

Indexed as

StrokeAgedChinaCohort StudiesEast Asian PeopleFemaleHumansIncidenceLongitudinal StudiesMaleMiddle AgedProspective StudiesRisk FactorsCardiometabolic IndexNonlinear relationshipObesityStrokeThe China Health and Retirement Longitudinal Study

Identifiers

PMID40082802
PMCPMC11905718

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.