Evidence map›Paper›PMID 40082818›Full record

ArticleBMC cancer2025

Novel genetic loci and functional properties of immune-related genes for colorectal cancer survival in Korea.

Dabin Yun, Jung-Ho Yang, Soyoun Yang, Jin-Ah Sim, Minjung Kim, Ji Won Park, Seung Yong Jeong, Aesun Shin, Sun-Seog Kweon, Nan Song

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Dabin Yun *College of Pharmacy, Chungbuk National University, Cheongju, Chungbuk, Korea.
Jung-Ho Yang *Department of Preventive Medicine, Chonnam National University Medical School, Hwasun, Jeonnam, Korea.
Soyoun YangCollege of Pharmacy, Chungbuk National University, Cheongju, Chungbuk, Korea.
Jin-Ah SimDepartment of AI Convergence, Hallym University, Chuncheon, Gangwon, Korea.
Minjung KimDepartment of Surgery, College of Medicine and Hospital, Seoul National University, Seoul, Korea.
Ji Won ParkDepartment of Surgery, College of Medicine and Hospital, Seoul National University, Seoul, Korea.
Seung Yong JeongDepartment of Surgery, College of Medicine and Hospital, Seoul National University, Seoul, Korea.
Aesun ShinDepartment of Preventive Medicine, College of Medicine, Seoul National University, Seoul, Korea.
Sun-Seog Kweon *Department of Preventive Medicine, Chonnam National University Medical School, Hwasun, Jeonnam, Korea.
Nan Song *College of Pharmacy, Chungbuk National University, Cheongju, Chungbuk, Korea. nan.song@chungbuk.ac.kr.

Funding

Chonnam National University Hwasun Hospital HCRI23004, HCRI21019Ministry of Science and ICT, South Korea RS-2024-00358322, 2022R1C1C1009902, RS-2024-00440787Seoul National University Hospital Cohort Research Fund 2520140010
6 · The paper itself

Abstract

One major topic in colorectal cancer (CRC) research is the role of immune cells against cancer cells. The association of single-nucleotide polymorphisms (SNPs) and polygenic risk scores (PRS) with CRC was examined and their functional properties were identified using a gene-gene interaction network. 960 CRC patients at Seoul National University Hospital (SNUH, discovery) and 6,627 CRC patients at Chonnam National University Hospital (CNNUH, validation) were enrolled. SNPs were genotyped using the Korean Biobank Array. 2,729 immune-related genes were selected from the Ensembl, Gene Ontology, and Kyoto Encyclopedia of Genes and Genomes, and 37,398 SNPs were mapped. PRS were categorized into tertiles. Cox proportional hazard models were fitted for overall survival (OS) and progression-free survival (PFS). A gene-gene interaction network was analyzed. Among CRC patients from SNUH, 154 (16.0%) died, while 245 (25.5%) had progression. In CNNUH, 3,537 (53.4%) died. For OS, the most significant association was observed for rs117322760 (8q23.1, PKHD1L1, hazard ratio (HR) = 4.58, p-value = 1.40 × 10

Indexed as

Colorectal NeoplasmsGenetic LociAgedFemaleGene Regulatory NetworksGenetic Predisposition to DiseaseHumansMaleMiddle AgedPolymorphism, Single NucleotidePrognosisRepublic of KoreaColorectal cancerGene-gene interaction networkImmune-related genePolygenic risk scoreSingle-nucleotide polymorphismSurvival

Identifiers

PMID40082818
PMCPMC11905532

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.