ArticleJournal of the American Chemical Society2025
Expansion of the Stereochemical Space of Triterpenes by Mining Noncanonical Oxidosqualene Cyclases Across the Diversity of Green Plants.
Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- High yield strategies for triterpenoid biosynthesis in cell factories.Journal of microbiology (Seoul, Korea) · 2026Review
- The potential of metabolic engineering for sustainable phytosterol production.Advanced biotechnology · 2026Review
- Protection and Delivery of Phytochemicals from Passive Encapsulation to Guaranteed Self-Assembly Induced by Amyloid Template for Chronic Disease Prevention via Modulating Microbial-Host Crosstalk.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Protein design drives synthetic biology research of plant natural products.Biodesign research · 2025Review
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Authors and funding
7 authors.
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Abstract
Triterpenoids and steroids are structurally complex polycyclic natural products with potent biological functions, for example, as hormones. In all eukaryotes, the carbon skeletons of these compounds are generated by oxidosqualene cyclases, which carry out a polycyclization cascade to generate four or five rings with up to nine stereogenic centers in a targeted manner. The tight stereochemical control of this cascade reaction severely limits the stereochemical space accessible by known oxidosqualene cyclases. Considering that naturally occurring hormone stereoisomers have markedly different biological activities, finding ways to produce stereoisomers of triterpenes would be highly desirable to open new avenues for developing triterpenoid and steroid drugs. Here, we present a plant kingdom-wide sequence mining approach based on sequence similarity networks to search for noncanonical oxidosqualene cyclases that might produce triterpene stereoisomers. From 1,891 oxidosqualene cyclase sequences representing the diversity of green plants, six candidates were selected for functional evaluation by heterologous production in
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