ArticleBrain and behavior2025
Breast Cancer and Meningioma Risk: A Mendelian Randomization Study.
Article in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Causal Associations of Cerebrospinal Fluid and Circulating Metabolites With Malignant Brain Neoplasms: A Mendelian Randomization Analysis.Brain and behavior · 2026Article
- Causal Link of Seven Trace Elements and Eight Nutrients With Meningioma: A Bidirectional Two-Sample Mendelian Randomization Analysis.Brain and behavior · 2025Article
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Authors and funding
6 authors.
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Abstract
backgroundThe exact nature of the link between breast cancer and meningiomas is unknown, although observational studies have shown a correlation between the two. Using a two-sample Mendelian randomization (MR) strategy, we aimed to investigate the effect of breast cancer on meningiomas.
methodsThree sets of genetic instruments were utilized in this study based on publicly available genetic summary data. For breast cancer, we selected 62 strongly associated SNPs; separate datasets were curated for HER2-positive and HER2-negative subtypes. MR analyses included outlier testing, MR-Egger regression, MR-PRESSO, weighted median, and inverse variance weighted approaches.
resultsThe inverse variance weighted analysis demonstrated significant evidence for breast cancer's effect on meningioma risk (OR = 1.213, 95% CI = 1.054-1.396, p = 0.007), supported by MR-Egger (OR = 1.456, 95% CI = 1.066-1.988, p = 0.021) though not by the weighted median method (OR = 1.095, 95% CI = 0.914-1.311, p = 0.326). Inverse variance weighting specifically revealed a significant association between HER2-positive breast cancer and meningioma incidence (OR = 1.203, 95% CI = 1.048-1.381, p = 0.009). Furthermore, breast cancer risk was associated with an increased incidence of malignant meningiomas (OR = 1.64, 95% CI = 1.12-2.40, p = 0.011).
conclusionsThis represents the first MR study investigating the causal relationship between breast cancer and meningiomas. Our findings support the hypothesis that breast cancer may increase meningioma risk.
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