ArticleFrontiers in neuroscience2025
Decoding tinnitus progression: neurochemical shifts in the anterior cingulate cortex revealed by magnetic resonance spectroscopy.
Article in Frontiers in neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- EEG microstates and dynamic functional connectivity reveal stage-specific brain networks in subjective tinnitus.iScience · 2026Article
- Pathophysiological Insights and Multimodal Interventions in Chronic Tinnitus, Anxiety, and Sleep Disorders.Nature and science of sleep · 2025Review
- Efficacy differences and predictors of personalized mixed acoustic therapy in chronic tinnitus patients with and without hearing loss.Frontiers in neurologyArticle
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Tinnitus persists as a significant public health challenge with elusive neurochemical underpinnings. Emerging evidence implicates dysregulated excitatory-inhibitory neurotransmission in the anterior cingulate cortex (ACC), a limbic-auditory hub governing tinnitus salience. This study investigates dynamic ACC neurochemical changes during tinnitus progression. Methods: Using single-voxel magnetic resonance spectroscopy (MRS), GABA+/creatine (Cr) and Glx (glutamate+glutamine)/Cr ratios were measured in the ACC of 16 recent-onset (RO; <6 months), 22 chronic (CH; ≥6 months) tinnitus patients, and 26 healthy controls (HC). Tinnitus severity was assessed via tinnitometry and Tinnitus Functional Index (TFI). Results: RO patients exhibited significantly reduced ACC GABA+/Cr compared to CH and HC groups ( Conclusion: Early tinnitus is characterized by ACC GABAergic deficits, while chronicity features normalized GABA+/Cr levels-suggesting compensatory neuroplastic restoration of inhibition over time. Glutamatergic activity may modulate perceptual and emotional dimensions of tinnitus. These phase-specific ACC neurochemical shifts highlight potential therapeutic targets for arresting tinnitus progression. Longitudinal studies are warranted to validate temporal dynamics.
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