ArticleNature. Mental health2025
Phenotypic divergence between individuals with self-reported autistic traits and clinically ascertained autism.
Article in Nature. Mental health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Neural Tracking of Social Navigation in Autism Spectrum Disorder.Biological psychiatry · 2026Article
- Obsessive-Compulsive Disorder (OCD) and Autism Spectrum Disorder (ASD): Clinical Fingerprints of the Comorbidity.Life (Basel, Switzerland) · 2026Article
- Stage-Specific Animate Attention Bias in Individuals with High and Low Autistic Traits: Behavioral and Eye-Tracking Evidence.Behavioral sciences (Basel, Switzerland) · 2026Article
- Reduced Affiliative Behavior in Autism Reflects Greater Dependence on Perceived Similarity.Research square · 2026Article
- Autism-associated learning patterns show reduced credit assignment to outcome-irrelevant features.Translational psychiatry · 2026Article
- Internal Consistency of Self-report Anxiety Measures for Autistic Adults Without Intellectual Disabilities: A Systematic Review and Meta-analysis.Journal of autism and developmental disorders · 2026Article
- Threading the Needle: Practical Considerations for Merging Theory-Driven Computational Psychiatry With Data-Driven Analytics to Enhance Precision Health at Scale.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Review
- Development and psychometric validation of a novel, self-report visual processing questionnaire (ViPro-SR) for neurodivergent adults.Current psychology (New Brunswick, N.J.) · 2026Article
- Internet gaming disorder among individuals with autism spectrum disorder in the Kingdom of Saudi Arabia: a comparative study.Frontiers in public health · 2026Article
- Visual orientation discrimination in adults with ADHD and ASD: the differential impact of clinical diagnosis and trait severity.Frontiers in psychiatry · 2026Article
- How working memory and reinforcement learning interact when avoiding punishment and pursuing reward concurrently.Journal of experimental psychology. General · 2025Article
- A unique neural and behavioral profile of social anxiety in autism.Research square · 2025Article
- Understanding depression in autism: the role of subjective perception and anterior cingulate cortex volume.Molecular autism · 2025Article
- Variability and stability of autistic traits in the general population: A systematic comparison between online and in-lab samples.Personality neuroscience · 2025Article
- Understanding Depression in Autism: The Role of Subjective Perception and Anterior Cingulate Cortex Volume.Research square · 2024Article
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Authors and funding
12 authors.
Funding
Abstract
While allowing for rapid recruitment of large samples, online research relies heavily on participants' self-reports of neuropsychiatric traits, foregoing the clinical characterizations available in laboratory settings. Autism spectrum disorder (ASD) research is one example for which the clinical validity of such an approach remains elusive. Here we compared 56 adults with ASD recruited in person and evaluated by clinicians to matched samples of adults recruited through an online platform (Prolific; 56 with high autistic traits and 56 with low autistic traits) and evaluated via self-reported surveys. Despite having comparable self-reported autistic traits, the online high-trait group reported significantly more social anxiety and avoidant symptoms than in-person ASD participants. Within the in-person sample, there was no relationship between self-rated and clinician-rated autistic traits, suggesting they may capture different aspects of ASD. The groups also differed in their social tendencies during two decision-making tasks; the in-person ASD group was less perceptive of opportunities for social influence and acted less affiliative toward virtual characters. These findings highlight the need for a differentiation between clinically ascertained and trait-defined samples in autism research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.