ArticleInternational journal of medical sciences2025
Specific immune landscape of heatstroke distinguished from sepsis and aseptic inflammation.
Article in International journal of medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- A New Paradigm for Precision Medicine in Heatstroke: From Molecular Subtyping to Targeted Prevention and Treatment.Journal of inflammation research · 2026Review
- The Dual Role of Natural Killer Cells in the Septic Liver.Journal of inflammation research · 2026Review
- Perioperative immune dynamics during cardiopulmonary bypass and association with major adverse postoperative events.Frontiers in cardiovascular medicine · 2026Article
- Sepsis and heatstroke: overlapping and distinct mechanisms of systemic inflammation.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025Review
- Heat stress-induced mitochondrial damage and its impact on leukocyte function.Journal of intensive care · 2025Review
- Prognostic nomogram for heat stroke patients based on rapidly accessible clinical indicators.Frontiers in medicine · 2025Article
- Molecular Mechanisms of Heatstroke: Pathophysiology and Cell Death Pathways.Juntendo medical journal · 2025Article
- Diagnosis and Management of Heat-related Illness: Clinical and Molecular Perspectives.Juntendo medical journal · 2025Review
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heatstroke is associated with immune system disturbances, which was similar to sepsis and aseptic inflammation. This study characterized the immune landscape of heatstroke and compared it to sepsis or aseptic inflammation in order to identify heatstroke-specific characteristics. We prospectively recruited 40 patients with heatstroke as well as the same number of age- and sex-matched healthy controls, patients with sepsis, or cardiopulmonary bypass-induced aseptic inflammation. Blood from the four groups was collected to perform spectral flow cytometry, single-cell RNA sequencing and protein chip assay to compare the profiles of T cells, B cells, monocytes, and natural killer cells. In patients with heatstroke, the relative abundance of TLR4
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.