Evidence map›Paper›PMID 40085182›Full record

ArticleObesity surgery2025

Fully Endoscopic One-Anastomosis Gastric Bypass in Adult Obese Minipigs: a Sham-Controlled Assessment of Two Bypass Limb Lengths.

Marc Barthet, Jean-Michel Gonzalez, Sohaib Ouazzani, Nicolas Cauche, Robin Najmaoui, Joyce Peetermans, Agostina Santoro-Schulte, Ornela Gjata, Eric Lombardini, Stephane Berdah

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Article in Obesity surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Marc BarthetAix-Marseille University, Marseille, France. marc.barthet@ap-hm.fr.
Jean-Michel GonzalezAix-Marseille University, Marseille, France.
Sohaib OuazzaniAix-Marseille University, Marseille, France.
Nicolas CaucheBrussels Medical Device Center (BMDC), Brussels, Belgium.
Robin NajmaouiBrussels Medical Device Center (BMDC), Brussels, Belgium.
Joyce PeetermansBoston Scientific Corporation, Marlborough, MA, USA.
Agostina Santoro-SchulteBoston Scientific Corporation, Marlborough, MA, USA.
Ornela GjataBoston Scientific Corporation, Marlborough, MA, USA.
Eric LombardiniBoston Scientific Corporation, Marlborough, MA, USA.
Stephane BerdahAix-Marseille University, Marseille, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe assessed the feasibility and safety of a fully endoscopic one-anastomosis gastric bypass (OAGB) procedure in obese adult minipigs, with short bypass limb length if feasible or full length in a sham-controlled study.

methodsA natural orifice transluminal endoscopic surgery (NOTES) OAGB procedure was performed in 4 obese adult Yucatan minipigs. Weight change was compared to 2 sham-controlled animals. Endoscopic examination and necropsy were performed at 15 weeks.

resultsA 50-cm bypass limb was unfeasible in the pigs, so the 4 test animals received 150-cm bypasses. By week 15, mean weight gain compared to baseline body weight was 3.6% in 3 surviving test animals and 10.5% in the 2 sham-controlled animals. Two asymptomatic gastrojejunal lumen-apposing metal stents and one asymptomatic duodenal exclusion device migration occurred during follow-up. One pig died on day 60 with intestinal volvulus finding on necropsy. In the surviving test pigs, bypass limb lengths were 360 cm, 120 cm, and 80 cm at necropsy.

conclusionsIn an experimental endoscopic OAGB procedure, a short bypass limb length was unfeasible in adult obese minipigs. Weight gain tended to be reduced in test animals with longer bypass limbs compared to sham-controlled animals. Additional safety testing is needed during the continued development of the procedure.

Indexed as

Gastric BypassNatural Orifice Endoscopic SurgeryObesityAnastomosis, SurgicalAnimalsDisease Models, AnimalFeasibility StudiesFemaleSwineSwine, MiniatureWeight GainBariatric surgeryEndoscopic gastroenterostomyGastric bypass/methodsGastrointestinal/methodsNatural orifice endoscopic surgery

Identifiers

PMID40085182

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.