Polydatin Mitigates Lead-Induced Nephropathy by Modulating Oxidative Stress, Inflammation, and the AMPK/AKT/Nrf2 Pathway in Rats.

Naief Dahran, Mohammad A Alobaidy, Wejdan H Owaydhah, Ehdaa K A Soubahi, Alaa A Eisa, Nani Nasreldin, Hossam Gadalla, Bassem Refaat, Mohamed E El-Boshy

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Article in Biological trace element research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it

0cells of the map it votes in

4citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

Renoprotective effects of vitamin D and thymoquinone, alone and in combination, in a rat co-treatment model of gentamicin-induced acute kidney injury.Molecular and cellular biochemistry · 2026
Article
The Protective Effect of Naringenin against Lead-Induced Hepatotoxicity in Rats: Mechanisms Involving Oxidative Stress Mitigation, Activation of PINK1/Parkin and Nrf2/NQO1 Pathways, and Autophagy Induction.Biological trace element research · 2026
Article
An Exploratory Analysis of Potential Core Targets and Signaling Pathways Linking Dexmedetomidine to Diabetes Insipidus: Integration of FAERS Pharmacovigilance Data, Network Toxicology and Clinical Transcriptomics.Drug design, development and therapy · 2026
Article
Role of the NLRP3 inflammasome in diabetes and its complications (Review).Molecular medicine reports · 2025
Review

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Naief DahranDepartment of Basic Medical Sciences, College of Medicine, University of Jeddah, Jeddah, Saudi Arabia.

Mohammad A AlobaidyDepartment of Anatomy, Faculty of Medicine, Umm Al-Qura University, P.O. Box 7607, Makkah, Saudi Arabia.

Wejdan H OwaydhahDepartment of Basic Medical Sciences, Faculty of Medicine, Taibah University, Madinah, Saudi Arabia.

Ehdaa K A SoubahiClinical Laboratory Department, Maternity and Children Hospital, Makkah, Saudi Arabia.

Alaa A EisaDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taibah University, Medina, Saudi Arabia.

Nani NasreldinDepartment of Pathology and Clinical Pathology, Faculty of Veterinary Medicine, New Valley University, P.O. Box 72511, El-Kharga, Egypt.

Hossam GadallaDepartment of Clinical Pathology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt.

Bassem RefaatDepartment of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Umm Al-Qura University, Prince Sultan Road, Al Abdeyah, 21955, Makkah, Saudi Arabia.

Mohamed E El-BoshyDepartment of Clinical Pathology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt. dr_elboshy@yahoo.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study investigated the molecular mechanisms underlying lead (Pb)-induced nephropathy and assessed the nephroprotective potential of Polydatin (PD). Forty male Wistar rats were divided into five groups (n = 8/group): negative control (NC), normal rats treated with 200 mg/kg/day of PD (NPD200), positive control (PC) receiving Pb only (30 mg/kg/day), and two groups co-administered Pb with PD (100 or 200 mg/kg/day). Serum and urine Pb levels were determined by an atomic absorption spectrophotometer. Markers of renal tissue damage (TGF-β/iNOS/NGLA/KIM-1) and renoprotective molecules (Nrf2/AMKα/AKT1) genes and proteins were measured by quantitative RT-PCR and Immunohistochemistry, respectively. ELISA was used to quantify markers of oxidative stress (GSH/Gpx1/CAT/MDA/H

Indexed as

GlucosidesInflammationKidney DiseasesLeadOxidative StressStilbenesAMP-Activated Protein KinasesAnimalsMaleNF-E2-Related Factor 2Proto-Oncogene Proteins c-aktRatsRats, WistarSignal TransductionAMP-Activated Protein KinasesGlucosidesLeadNfe2l2 protein, ratNF-E2-Related Factor 2polydatinProto-Oncogene Proteins c-aktStilbenesGlutathioneHeavy metal-induced nephrotoxicityInducible nitric oxide synthaseKidney injury molecule-1Neutrophil gelatinase-associated lipocalinTransforming growth factor-β

Identifiers

PMID40085304

DOI10.1016/j.scitotenv.2019.134901

What Socratic holds

Textmetadata

Read underepoch 390

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.