SynthesisCurrent nutrition reports2025
Antioxidant Supplementation for Management of Gestational Diabetes Mellitus in Pregnancy: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.
Synthesis in Current nutrition reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Dietary fiber supplementation mitigates gestational diabetes risk and preterm birth via gut microbiota modulation: a randomized controlled trial.Frontiers in endocrinology · 2026Trial
- Potential Involvement of Redox and Inflammatory Signalling in the Antihyperglycemic and Antioxidant Effects of Harmaline in Male Mice With Type 2 Diabetes.Endocrinology, diabetes & metabolism · 2026Article
- Redox Imbalance in Gestational Diabetes Mellitus: Mechanistic Insights, Emerging Biomarkers, and Therapeutic Perspectives.International journal of molecular sciences · 2026Review
- Oxidative stress, mitochondrial dysfunction, and ferroptosis in the placenta of gestational diabetes mellitus.Journal of molecular medicine (Berlin, Germany) · 2025Review
- Impact of Mediterranean Dietary Intervention on Reactive Oxygen Species Levels and Total Antioxidant Capacity During Pregnancy.Current issues in molecular biology · 2025Article
- Pregnancy Under Pressure: Oxidative Stress as a Common Thread in Maternal Disorders.Life (Basel, Switzerland) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewGestational diabetes mellitus (GDM) is the most common medical complication of pregnancy globally. Hyperglycaemia and associated production of reactive oxygen species can lead to oxidative stress in pregnancy. However, the potential effectiveness of increased antioxidant intake in the management of GDM has not been widely examined. Its usefulness alongside medical nutrition therapy (MNT) for assisting glycaemic control in women with GDM is poorly understood. This review aimed to establish the effect of antioxidant supplementation on the risk and management of gestational diabetes mellitus (GDM). RECENT
findingsA systematic review of intervention studies was conducted based on PRISMA guidelines. Databases searched were MEDLINE, CINAHL, Global Health, Scopus, Embase and Cochrane until September 2024. Random effects meta-analyses using Cochrane Review Manager software to establish the effect of antioxidant supplementation on glucose outcomes in women with GDM were conducted. A total of 13 studies (1380 participants) were included in the review with four different antioxidants used (selenium (n = 3); alpha-lipoic (n = 4); zinc (n = 5); e-3-gallate (n = 1)). Significant pre-post differences between antioxidant supplementation and control groups were found for fasting insulin (SMD, 95%CI) (-0.97 [-1.69 -0.24]; p = 0.009, HOMA-IR (-0.90 [-1.25, -0.54]; p < 0.0000, HOMA-B (-0.86 [-1.05, -0.67]; p < 0.00001 and QUICKI (1.09 [0.32,1.87]; p = 0.005 Heterogeneity was substantial (I
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.