Evidence map›Paper›PMID 40085352›Full record

ArticleMolecular neurobiology2025

From Clinic to Mechanisms: Multi-Omics Provide New Insights into Cerebrospinal Fluid Metabolites and the Spectrum of Psychiatric Disorders.

Jie Wen, Yingjie Li, Yu Chen, Yongzhen Li, Bin Yu, Hongwei Liu, Zhiwei Xia, Jingwei Zhang

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jie Wen *Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China.
Yingjie Li *Department of Infectious Diseases, The Second Xiangya Hospital, Central South University, Changsha, China.
Yu ChenDepartment of Neurosurgery, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Yongzhen LiDepartment of Pediatrics, The Second Xiangya Hospital, Central South University, Changsha, China.
Bin YuDepartment of Neurosurgery, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Hongwei LiuDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China.
Zhiwei XiaDepartment of Neurology, Hunan Aerospace Hospital, Hunan Normal University, Changsha, China. xiazhiwei2011@gmail.com.
Jingwei ZhangDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China. xyyyzjw@csu.edu.cn.

Funding

National Natural Science Foundation of China 82401594Natural Science Foundation of Hunan Province 2022JJ30943Natural Science Foundation of Hunan Province 2023JJ30971
6 · The paper itself

Abstract

Cerebrospinal fluid (CSF) is crucial in maintaining brain homeostasis by facilitating waste clearance, nutrient transport, and immune signaling. However, the links between CSF metabolites and psychiatric disorders, as well as the underlying mechanisms, remain largely unexamined. We conducted a bidirectional two-sample Mendelian randomization analysis to investigate potential causal relationships between CSF metabolites and 12 psychiatric disorders. Summary data for psychiatric disorders were sourced from the Psychiatric Genomics Consortium, while information on CSF metabolites was derived from two studies within the Wisconsin Alzheimer's Disease cohort. Causal estimates and pleiotropy were assessed using several robust methods, including inverse-variance-weighted (IVW) analysis, weighted median analysis, MR-Egger regression, and the MR-Egger test. Furthermore, a transcriptome-wide association study was conducted to explore potential mechanisms and shared etiologies between CSF metabolites and psychiatric disorders. The genetic risk of eating disorders (ED) can be increased by leucine (OR = 1.55, 95% CI: 1.21-1.97, P = 4.35 × 10⁻

Indexed as

Mental DisordersMetabolomeMetabolomicsFemaleGenome-Wide Association StudyHumansMaleMendelian Randomization AnalysisMultiomicsCerebrospinal fluid metabolitesMendelian randomizationPsychiatric disordersTranscriptome-wide association study

Identifiers

PMID40085352

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.