Evidence map›Paper›PMID 40085357›Full record

ReviewMolecular neurobiology2025

The Role of Choroid Plexus in Hydrocephalus from the Perspective of Structure and Function: a Therapeutic Target.

Ziang Deng, Haoxiang Wang, Kunhong Zhong, Yuanyou Li, Huajiang Deng, Baocheng Gao, Keru Huang, Aiping Tong, Liangxue Zhou

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ziang DengDepartment of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China.ORCID http://orcid.org/0000-0002-9604-7502
Haoxiang WangDepartment of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China.
Kunhong ZhongState Key Laboratory of Biotherapy and Cancer Center, Research Unit of Gene and Immunotherapy, Chinese Academy of Medical Sciences, Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Yuanyou LiDepartment of Pediatric Neurosurgery, West China Second University Hospital, Sichuan University, Chengdu, China.
Huajiang DengDepartment of Neurosurgery, Affiliated Hospital of Southwest Medical University, Sichuan Province, Luzhou City, China.
Baocheng GaoDepartment of Neurosurgery, The First People'S Hospital of Yunnan Province, the Affiliated Hospital of Kunming University of Science and Technology) Kunming, Yunan, China.
Keru HuangDepartment of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China.
Aiping TongState Key Laboratory of Biotherapy and Cancer Center, Research Unit of Gene and Immunotherapy, Chinese Academy of Medical Sciences, Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu, China. aipingtong@scu.edu.cn.
Liangxue ZhouDepartment of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China. Zhlxlll@163.com.ORCID http://orcid.org/0000-0001-9991-6358

Funding

Major Scientific and Technological Achievements Transformation Project of Ningxia Hui Autonomous Region 2022CJE09013Mianyang Key Laboratory of Anesthesia and Neuroregulation MZSJ202304National Natural Science Foundation of China 82473334NHC Key Laboratory of Nuclear Technology Medical Transformation (Miyang Central hospital) 2023HYX001; 2023HYX014
6 · The paper itself

Abstract

Hydrocephalus is one of the most common neurological diseases, characterized by abnormal excessive accumulation of cerebrospinal fluid (CSF) in the ventricular system. Its pathophysiological mechanism is believed to be related to the imbalance of CSF circulation and homeostasis. As the main source of CSF secretion, the choroid plexus is closely related to hydrocephalus. The choroid plexus is a specialized vascularized tissue located within the cerebral ventricles. It has multiple physiological functions including regulating CSF, immune response, endocrine metabolism, etc. Strategies that reduce choroid plexus CSF secretion have been shown to be effective in the treatment of hydrocephalus. However, the role of other physiological functions of the choroid plexus in hydrocephalus is still unclear. Recent studies on the choroid plexus and the blood-CSF barrier have deepened our understanding of the structure and function of the choroid plexus. The idea of targeting the choroid plexus to treat hydrocephalus has spawned many branches: choroid plexus epithelial cells, choroid plexus immune cells, choroid plexus peptides, and choroid plexus cilia, etc. This review introduces the basic structure and function of the choroid plexus, summarizes their changes in hydrocephalus, and analyzes the possibility of the choroid plexus as a therapeutic target for hydrocephalus.

Indexed as

Choroid PlexusHydrocephalusAnimalsBlood-Brain BarrierHumansCerebrospinal fluidChoroid plexusHydrocephalusPathophysiologyTargetTreatment

Identifiers

PMID40085357

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.