Evidence map›Paper›PMID 40085493›Full record

ArticleAmerican journal of respiratory cell and molecular biology2025

The Critical Role of HMGB1Cys106 in Regulating Sex-Specific p53 Signaling in Pulmonary Arterial Hypertension.

Odunayo Susan Lawal, Maki Niihori, Joel James, A J Hinkle, Takanori Sano, Nolan McClain, Ruslan Rafikov, Olga Rafikova

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Odunayo Susan LawalDivision of Pulmonary, Critical Care, Sleep, and Occupational Medicine, Department of Medicine, Indiana University, Indianapolis, Indiana; and.
Maki NiihoriDivision of Pulmonary, Critical Care, Sleep, and Occupational Medicine, Department of Medicine, Indiana University, Indianapolis, Indiana; and.
Joel JamesDivision of Pulmonary, Critical Care, Sleep, and Occupational Medicine, Department of Medicine, Indiana University, Indianapolis, Indiana; and.
A J HinkleDivision of Pulmonary, Critical Care, Sleep, and Occupational Medicine, Department of Medicine, Indiana University, Indianapolis, Indiana; and.
Takanori SanoDivision of Pulmonary, Critical Care, Sleep, and Occupational Medicine, Department of Medicine, Indiana University, Indianapolis, Indiana; and.
Nolan McClainDivision of Endocrinology, Department of Medicine, University of Arizona, Tucson, Arizona.
Ruslan RafikovDivision of Pulmonary, Critical Care, Sleep, and Occupational Medicine, Department of Medicine, Indiana University, Indianapolis, Indiana; and.
Olga RafikovaDivision of Pulmonary, Critical Care, Sleep, and Occupational Medicine, Department of Medicine, Indiana University, Indianapolis, Indiana; and.

Funding

Anaplerotic reprogramming of endothelial cells in pulmonary hypertension.R01HL132918 · NHLBI · UNIVERSITY OF ARIZONA · PI RAFIKOV, RUSLAN · 2016 to 2025
$4.5M
Hemolysis and Free Heme Signaling in Pulmonary HypertensionR01HL151447 · NHLBI · UNIVERSITY OF ARIZONA · PI Ruslan Rafikov · 2020 to 2026
$4.3M
Mitochondrial Dysfunction in Pulmonary HypertensionR01HL160666 · NHLBI · UNIVERSITY OF ARIZONA · PI Olga Rafikova · 2022 to 2026
$3.3M
HMGBG1 and Gender Difference in Pulmonary Arterial HypertensionR01HL133085 · NHLBI · UNIVERSITY OF ARIZONA · PI RAFIKOVA, OLGA · 2016 to 2020
$1.9M
American Heart Association 23CDA1050843American Heart Association 23DIVSUP1065885American Heart Association 969574American Heart Association-American Stroke Association 969574NHLBI NIH HHS R01 HL132918NHLBI NIH HHS R01HL132918NHLBI NIH HHS R01HL133085NHLBI NIH HHS R01 HL151447NHLBI NIH HHS R01HL151447NHLBI NIH HHS R01 HL160666NHLBI NIH HHS R01HL160666
6 · The paper itself

Abstract

HMGB1 (High Mobility Group Box 1) is a nuclear protein released from damaged cells and implicated in the pathogenesis of pulmonary arterial hypertension (PAH) through activation of proinflammatory and prosurvival responses. However, the role of intracellular HMGB1 signaling, particularly its interactions with DNA and transcriptional regulation, remains underexplored. In this study, we investigated the role of intracellular HMGB1 and its critical residue Cys106 by engineering cell-penetrating peptide (αHMGB1Cys106) that mimics part of the HMGB1 dimeric interface surrounding Cys106. The peptide's effects on HMGB1 intracellular distribution, DNA-binding affinity, and p53 expression and signaling were assessed in cell culture and

Indexed as

CysteineHMGB1 ProteinHypertension, PulmonaryPulmonary Arterial HypertensionSignal TransductionTumor Suppressor Protein p53AnimalsApoptosisDisease Models, AnimalDNA DamageFemaleHumansMaleRatsRats, Sprague-DawleyCysteineHbp1 protein, ratHMGB1 ProteinTumor Suppressor Protein p53HMGB1p53pulmonary arterial hypertension

Identifiers

PMID40085493
PMCPMC12416316

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.