Evidence map›Paper›PMID 40085997›Full record

ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2025

Repeated spaced paired-associative stimulation to the parietal-motor pathway maintains corticomotor excitability in older adults.

Elana R Goldenkoff, Joseph A Deluisi, James A Brissenden, Taraz G Lee, Thad A Polk, Stephan F Taylor, Benjamin M Hampstead, Michael Vesia

Abstract read
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In one paragraph

Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Elana R GoldenkoffSchool of Kinesiology, University of Michigan, Ann Arbor, USA.
Joseph A DeluisiSchool of Kinesiology, University of Michigan, Ann Arbor, USA.
James A BrissendenDepartment of Psychology, University of Michigan, Ann Arbor, USA.
Taraz G LeeDepartment of Psychology, University of Michigan, Ann Arbor, USA.
Thad A PolkDepartment of Psychology, University of Michigan, Ann Arbor, USA.
Stephan F TaylorDepartment of Psychiatry, University of Michigan, Ann Arbor, USA.
Benjamin M HampsteadDepartment of Psychiatry, University of Michigan, Ann Arbor, USA; Department of Neurology, University of Michigan, Ann Arbor, USA.
Michael VesiaSchool of Kinesiology, University of Michigan, Ann Arbor, USA. Electronic address: mvesia@umich.edu.

Funding

Research Program on Cognition and Neuromodulation Based Interventions (RP-CNBI)R35AG072262 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HAMPSTEAD, BENJAMIN MICHAEL · 2021 to 2025
$4.2M
Leveraging behavioral state to enhance specificity of non-invasive brain stimulation on motor circuitsR21NS118055 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI VESIA, MICHAEL · 2021 to 2021
$429k
NIA NIH HHS R35 AG072262NINDS NIH HHS R21 NS118055
6 · The paper itself

Abstract

introductionCortical paired associative stimulation (cPAS), repeated at spaced intervals and applied to the primary motor cortex (M1) and posterior parietal cortex (PPC), has a dose-dependent effect on corticomotor excitability in young adults. The present study investigated whether aging affects this additive (nonhomeostatic) metaplasticity by performing the same manipulation in a sample of older adults.

methodsIn the multi-dose cPAS condition, three consecutive sessions of the Hebbian-plasticity-induction cPAS protocol were administered with a 50-minute interval between sessions. In the single-dose control cPAS condition, one session of the Hebbian-plasticity-induction cPAS protocol was followed by two sessions of a control non-Hebbian cPAS protocol. We measured motor-evoked potentials (MEPs) before and after each cPAS session.

resultsCompared to a single dose of cPAS, the multi-dose cPAS protocol prevented the reduction in MEP amplitude, resulting in relatively greater corticomotor excitability following the Hebbian procedures. We did not find evidence for an increase in MEP amplitude after the repeated, spaced Hebbian-plasticity-induction cPAS protocol from baseline levels, suggesting reduced neuroplasticity in older adults compared to young adults.

conclusionRepeated spaced paired-associative stimulation to the parietal-motor pathway maintains corticomotor excitability in older adults. SIGNIFICANCE: These findings provide insight into age-related differences in neuroplastic capacity in healthy humans.

Indexed as

AgingEvoked Potentials, MotorMotor CortexNeuronal PlasticityParietal LobeTranscranial Magnetic StimulationAdultAgedElectromyographyFemaleHumansMaleMiddle AgedAgingCortical paired associative stimulationFunctional connectivityParietal-motor networkPlasticityTranscranial magnetic stimulation

Identifiers

PMID40085997
PMCPMC12058389

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.