Evidence map›Paper›PMID 40087174›Full record

Trial reportPsychopharmacology2025

The behavioural effects of the serotonin 1A receptor agonist buspirone on cognition and emotional processing in healthy volunteers.

Alexander L W Smith, Sorcha Hamilton, Susannah E Murphy, Philip J Cowen, Catherine J Harmer

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Psychopharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Alexander L W SmithDepartment of Psychiatry, Warneford Hospital, University of Oxford, Oxford, OX3 7JX, UK. alexander.smith@psych.ox.ac.uk.
Sorcha HamiltonDepartment of Psychiatry, Warneford Hospital, University of Oxford, Oxford, OX3 7JX, UK.
Susannah E MurphyDepartment of Psychiatry, Warneford Hospital, University of Oxford, Oxford, OX3 7JX, UK.
Philip J CowenDepartment of Psychiatry, Warneford Hospital, University of Oxford, Oxford, OX3 7JX, UK.
Catherine J HarmerDepartment of Psychiatry, Warneford Hospital, University of Oxford, Oxford, OX3 7JX, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

rationaleThe 5-HT

objectivesThe current study tested the acute effects of a single dose of the 5-HT

resultsBuspirone reduced accuracy for detection of facial expressions of disgust and increased misclassification of negative facial emotions. It had no significant effects on categorisation or recall of emotionally-valanced words. Buspirone also reduced recall accuracy in the AVLT but had no significant effect in the N-back task. Participants receiving buspirone were more likely to experience nausea, light-headedness and sleepiness.

conclusionsAcute buspirone administration produced a mild impairment in verbal memory and a subtle negative bias in emotional processing in healthy volunteers. These effects are consistent with the mixed effects of buspirone on pre- and post-synaptic 5-HT

Indexed as

BuspironeCognitionEmotionsSerotonin 5-HT1 Receptor AgonistsAdultDouble-Blind MethodFacial ExpressionFemaleHealthy VolunteersHumansMaleMental RecallReceptor, Serotonin, 5-HT1AVerbal LearningYoung AdultBuspironeReceptor, Serotonin, 5-HT1ASerotonin 5-HT1 Receptor Agonists5-HTBuspironeCognitionDepressionEmotionSerotonin

Identifiers

PMID40087174
PMCPMC12296846

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.