Evidence map›Paper›PMID 40087189›Full record

ArticleEJNMMI research2025

Heart ketone metabolism under acute ketone supplementation in ZDF rats, a type 2 diabetes heart failure model.

Etienne Croteau, Gabriel Richard, Patrick Prud'Homme, Etienne Rousseau, Stephen C Cunnane, Véronique Dumulon-Perreault, Otman Sarrhini, Serge Phoenix, Sébastien Tremblay, Brigitte Guérin and 1 more

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In one paragraph

Article in EJNMMI research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Etienne CroteauSherbrooke Molecular Imaging Centre (CIMS), CRCHUS, Sherbrooke, QC, Canada. Etienne.Croteau@USherbrooke.ca.ORCID http://orcid.org/0000-0002-4971-6443
Gabriel RichardSherbrooke Molecular Imaging Centre (CIMS), CRCHUS, Sherbrooke, QC, Canada.
Patrick Prud'HommeDepartment of Cardiology, Université de Sherbrooke, Sherbrooke, QC, Canada.
Etienne RousseauDepartment of Medical Imaging and Radiation Sciences, Université de Sherbrooke, Sherbrooke, QC, Canada.
Stephen C CunnaneResearch Center on Aging, Université de Sherbrooke, Sherbrooke, QC, Canada.
Véronique Dumulon-PerreaultSherbrooke Molecular Imaging Centre (CIMS), CRCHUS, Sherbrooke, QC, Canada.
Otman SarrhiniSherbrooke Molecular Imaging Centre (CIMS), CRCHUS, Sherbrooke, QC, Canada.
Serge PhoenixSherbrooke Molecular Imaging Centre (CIMS), CRCHUS, Sherbrooke, QC, Canada.
Sébastien TremblaySherbrooke Molecular Imaging Centre (CIMS), CRCHUS, Sherbrooke, QC, Canada.
Brigitte GuérinSherbrooke Molecular Imaging Centre (CIMS), CRCHUS, Sherbrooke, QC, Canada.
Roger LecomteSherbrooke Molecular Imaging Centre (CIMS), CRCHUS, Sherbrooke, QC, Canada.

Funding

Faculté de médecine et des sciences de la santé, Université de Sherbrooke Faculté de médecine et des sciences de la santé, Université de Sherbrooke
6 · The paper itself

Abstract

backgroundIn non-insulin-dependent, type 2, diabetes mellitus (T2D), glucose metabolism is compromised, and the heart loses its metabolic flexibility. The Zucker Diabetic Fatty rat (ZDF) model, which replicates the pathophysiology of T2D in patients, shows that as T2D progresses so does heart failure. Heart ketone metabolism seems to play a role in mitigating the heart failure process. This study assesses ketone metabolism in a ZDF heart failure model using cardiac PET imaging.

methodsSix lean ZDF rats (CTRL) and six diabetic obese ZDF rats (T2D) were evaluated for coronary flow reserve (CFR) using [

resultsCFR was impaired in the T2D model (CTRL: 1.8 ± 0.5; T2D: 1.4 ± 0.2, p < 0.05) suggesting the development of heart failure in the T2D model. Blood ketones increased more than 2-fold after supplementation. The [

conclusionIn a rat model of T2D and CFR impairment, we were able to measure changes in ketone metabolism using [

Indexed as

AcetoacetateBeta-hydroxybutyrateHeart failureKetone bodiesMyocardial blood flowPositron emission tomographyType II diabetes

Identifiers

PMID40087189
PMCPMC11909378

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.