ArticleScientific reports2025
Physical activity reverses the aging induced decline in angiogenic potential in the fast locomotory muscles of mice.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The role of exercise induced capillarization adaptations in skeletal muscle aging: a systematic review.Frontiers in physiology · 2025Pooled it
- Sarcopenia and Muscle Aging: Updated Insights into Molecular Mechanisms and Translational Therapeutics.Endocrinology and metabolism (Seoul, Korea) · 2026Review
- Voluntary wheel running promotes lymphangiogenesis in slow-twitch muscle in young mice.Frontiers in physiology · 2025Article
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Authors and funding
6 authors.
Funding
Abstract
Fast locomotory muscles, which are responsible for generating the highest power outputs, are more vulnerable to aging than slow muscles. In this study, we aimed to evaluate the impact of middle age and voluntary physical activity on capillarization and angiogenic potential in fast locomotory muscles. Middle-aged (M-group) and young (Y-group) wild-type FVB female mice were randomly assigned to either the sedentary or trained group undergoing 8-week spontaneous wheel running (8-sWR). Capillary density (assessed via immunohistochemical capillary staining and Western immunoblotting) of the fast locomotory muscles in the M-group (15-months old) was not significantly different compared to the Y-group (4-months old). Nevertheless, the expression of key pro-angiogenic genes in the fast muscle of the M-group was lower than that in the fast muscle of Y-group. 8-sWR had no impact on muscle capillarization; however, it increased fast muscle Vegfa expression in both the M and Y groups. We concluded that although fast muscle capillarization is still preserved in middle age, nevertheless the angiogenic potential (at least at the level of gene expression) is significantly reduced at this stage of aging. Moderate-intensity voluntary physical activity had no effect on capillary density, but it increased the angiogenic potential of the fast muscle.
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Registered trials
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