Evidence map›Paper›PMID 40087654›Full record

ArticleInternational journal for equity in health2025

Identifying mechanisms by which social determinants of health impact TB diagnostic evaluation uptake in Uganda: a qualitative study.

Talemwa Nalugwa, Kristi Sidney Annerstedt, Sarah Nabwire, Nora S West, Jillian L Kadota, Salla Atkins, Adithya Cattamanchi, Knut Lönnroth, Achilles Katamba, Priya B Shete

Abstract read
In one paragraph

Article in International journal for equity in health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Tuberculosis: An Ongoing Global Threat.Advances in experimental medicine and biology · 2026
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Talemwa Nalugwa *World Alliance for Lung and Intensive Care Medicine in Uganda (WALIMU), Kampala, Uganda.
Kristi Sidney Annerstedt *Department of Global Public Health, Karolinska Institutet, WHO TB Collaborating center, Stockholm, Sweden.
Sarah NabwireWorld Alliance for Lung and Intensive Care Medicine in Uganda (WALIMU), Kampala, Uganda.
Nora S WestDivision of Pulmonary and Critical Care Medicine, University of California San Francisco, San Francisco, CA, USA.
Jillian L KadotaDivision of Pulmonary and Critical Care Medicine, University of California San Francisco, San Francisco, CA, USA.
Salla AtkinsDepartment of Global Public Health, Karolinska Institutet, WHO TB Collaborating center, Stockholm, Sweden.
Adithya CattamanchiWorld Alliance for Lung and Intensive Care Medicine in Uganda (WALIMU), Kampala, Uganda.
Knut LönnrothDepartment of Global Public Health, Karolinska Institutet, WHO TB Collaborating center, Stockholm, Sweden.
Achilles KatambaWorld Alliance for Lung and Intensive Care Medicine in Uganda (WALIMU), Kampala, Uganda.
Priya B SheteWorld Alliance for Lung and Intensive Care Medicine in Uganda (WALIMU), Kampala, Uganda. Priya.Shete@ucsf.edu.

Funding

Virology CoreP30AI027763 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STEVEN Grant DEEKS · 1988 to 2026
$93.6M
Improving the molecular diagnosis of drug resistant tuberculosisR01AI121144 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CATTAMANCHI, ADITHYA, KATO-MAEDA, MIDORI · 2016 to 2020
$3.6M
NIAID NIH HHS P30 AI027763NIAID NIH HHS R01 AI121144NIH HHS NIH/NHLBI R01AI121144Swedish Research Council A134183UCSF-Gladstone Center for AIDS Research AI027763
6 · The paper itself

Abstract

backgroundSocial and structural determinants of health (SDoH) are associated with tuberculosis (TB) outcomes but often unaddressed in TB care programs. We sought to describe the mechanism by which SDoH impact completion of TB diagnostic evaluation in Uganda using an implementation science framework rooted in behavioral theory.

methodsTrained research staff interviewed 24 purposively sampled adults undergoing TB diagnostic evaluation at six community health centers in Uganda between February-August 2019. Framework analysis was used to construct themes linked to SDoH across the TB diagnostic evaluation cascade of care. Themes were then mapped to domains of the capability, opportunity, and motivation behavior change model (COM-B).

resultsBarriers related to SDoH were identified across the diagnostic evaluation cascade of care and associated with domains central to uptake of testing and treatment. These included: limited knowledge about TB diagnosis and treatment (psychological capability); low socioeconomic status and competing financial priorities (physical opportunity); internalized and anticipated stigma of TB diagnosis, lack of social support programs and limited social support/social capital (social opportunity, reflective motivation); trust (or distrust) in the government health facility to provide quality care (reflective motivation); and fear and shame about worsening poverty (automatic motivation). Facilitators to engagement with the TB cascade of care included encouragement from friends and family to seek testing (automatic motivation, social opportunity), and trust that healthcare providers were acting in their best interests (social opportunity).

conclusionsBiomedical interventions alone are unlikely to address the spectrum of SDoH-related barriers to equitable completion of TB diagnostic evaluation. Linking barriers to a behavior change model such as COM-B may help guide the design and evaluation of appropriate people-centered strategies that integrate social and economic supports with clinical and public health programs or services.

Indexed as

Social Determinants of HealthTuberculosisAdultFemaleHumansMaleMiddle AgedMotivationQualitative ResearchSocial StigmaSocial SupportUgandaCOM-B modelQualitative researchSocial determinants of healthTuberculosis

Identifiers

PMID40087654
PMCPMC11909805

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.