Evidence map›Paper›PMID 40087728›Full record

ArticleJournal of neuroinflammation2025

Chronic intermittent hypoxia disrupts protective microgliosis in ischemic proliferative retinopathy.

Tianxiang Yang, Kaitryn E Ronning, Sébastien Augustin, Frédéric Blond, Caroline Nous, Foteini Argyriou, Sara Touhami, Cécile Delarasse, Xavier Guillonneau, Florian Sennlaub

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroinflammation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tianxiang Yang *Sorbonne University, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, Paris, F-75012, France.
Kaitryn E Ronning *Sorbonne University, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, Paris, F-75012, France.
Sébastien AugustinSorbonne University, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, Paris, F-75012, France.
Frédéric BlondSorbonne University, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, Paris, F-75012, France.
Caroline NousCentre Hospitalier National d'Ophtalmologie des Quinze-Vingts, INSERM-DHOS CIC 503, Paris, France.
Foteini ArgyriouSorbonne University, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, Paris, F-75012, France.
Sara TouhamiPitié Salpêtrière University Hospital, Sorbonne Université, 47-83 Boulevard de l'Hôpital, Paris, 75013, France.
Cécile Delarasse *Sorbonne University, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, Paris, F-75012, France.
Xavier Guillonneau *Sorbonne University, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, Paris, F-75012, France.
Florian Sennlaub *Sorbonne University, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, Paris, F-75012, France. florian.sennlaub@inserm.fr.

Funding

Agence Nationale de la Recherche ANR-18-CE14-0031-02Union Nationale des Aveugles et Déficients Visuels AMoDel
6 · The paper itself

Abstract

Sleep apnea that leads to chronic intermittent hypoxia (CIH) is an independent risk factor for advanced, debilitating ischemic proliferative retinopathies, such as diabetic retinopathy (DR) and retinopathy of prematurity (ROP). The underlying mechanisms are unknown. Here we investigated the consequences of CIH on the ischemic retina of the oxygen-induced retinopathy model. We show that experimental CIH inhibited colony stimulating factor 1 (CSF1) expression, blunting the reactive microgliosis during the ischemic phase of OIR. CIH severely delayed beneficial revascularization of the ischemic retina and increased pathological neovascularization. CIH also induced photoreceptor segment thinning and accentuated OIR-induced inner and outer retinal functional deficits. Mechanistically we demonstrated that local CSF1R inhibition during ischemic retinopathy reduced the number of microglial cells, inhibited revascularization, and exacerbated pathological neovascularization, recapitulating the effects of CIH. Our findings provide a novel mechanism by which sleep apnea and CIH aggravate ischemic retinopathies, underscoring the importance of treating apnea in DR and ROP to help prevent sight threatening severe disease.

Indexed as

GliosisHypoxiaIschemiaMicrogliaRetinopathy of PrematurityAnimalsAnimals, NewbornDisease Models, AnimalMiceMice, Inbred C57BLRetinaHypoxiaIschemic retinopathyMicrogliaSleep apnea

Identifiers

PMID40087728
PMCPMC11909870

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.