Evidence map›Paper›PMID 40088136›Full record

ArticleWorld journal of surgery2025

Intraoperative Blood Loss Predicts Local Recurrence After Curative Resection for Stage I-III Colorectal Cancer.

Kouki Imaoka, Manabu Shimomura, Hiroshi Okuda, Takuya Yano, Wataru Shimizu, Masanori Yoshimitsu, Satoshi Ikeda, Masahiro Nakahara, Mohei Kohyama, Hironori Kobayashi and 13 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Kouki ImaokaDepartment of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.ORCID 0000-0001-8972-5777
Manabu ShimomuraDepartment of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Hiroshi OkudaDepartment of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Takuya YanoDepartment of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Wataru ShimizuDepartment of Surgery, Hiroshima City North Medical Center Asa Citizens Hospital, Hiroshima, Japan.
Masanori YoshimitsuDepartment of Surgery, Hiroshima City Hiroshima Citizens Hospital, Hiroshima, Japan.
Satoshi IkedaDepartment of Gastroenterological Surgery, Hiroshima Prefectural Hospital, Hiroshima, Japan.
Masahiro NakaharaDepartment of Surgery, Onomichi General Hospital, Onomichi, Japan.
Mohei KohyamaDepartment of Surgery, Hiroshima General Hospital, Hatsukaichi, Japan.
Hironori KobayashiDepartment of Surgery, Hiroshima Memorial Hospital, Hiroshima, Japan.
Yosuke ShimizuDepartment of Surgery, Kure Medical Center/Chugoku Cancer Center, Institute for Clinical Research, Kure, Japan.
Masatoshi KochiDepartment of Surgery, National Hospital Organization Higashihiroshima Medical Center, Higashihiroshima, Japan.
Shintaro AkabaneDepartment of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Daisuke SumitaniDepartment of Surgery, JR Hiroshima Hospital, Hiroshima, Japan.
Shoichiro MukaiDepartment of Surgery, Chugoku Rosai Hospital, Kure, Japan.
Yuji TakakuraDepartment of Surgery, Chuden Hospital, Hiroshima, Japan.
Yasuyo IshizakiDepartment of Surgery, National Hospital Organization Hiroshima-Nishi Medical Center, Otake, Japan.
Shinya KodamaDepartment of Surgery, Yoshida General Hospital, Akitakata, Japan.
Masahiko FujimoriDepartment of Surgery, Kure City Medical Association Hospital, Kure, Japan.
Sho IshikawaDepartment of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Tomohiro AdachiDepartment of Surgery, Hiroshima City North Medical Center Asa Citizens Hospital, Hiroshima, Japan.
Minoru HattoriAdvanced Medical Skills Training Center, Institute of Biomedical and Health Science, Hiroshima University, Hiroshima, Japan.
Hideki OhdanDepartment of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo identify the predictors of local recurrence and distant metastasis after radical surgery for stage I-III colorectal cancer. MATERIALS AND

methodsPatient and tumor characteristics, clinicopathological stages, perioperative factors, and postoperative outcomes, including local and distant recurrence, of patients who underwent primary colorectal resection were evaluated in this multicenter retrospective analysis. Univariate and multivariate regression analyses were performed to identify the risk factors for local and distant recurrences, with a focus on the intraoperative blood loss (IBL) ratio [IBL (mL)/total blood volume (mL)] and postoperative complications.

resultsThe risk factors for local and distant recurrence pattern differed. The predictors for local recurrence included perioperative factors, such as the IBL ratio and anastomotic leakage, as well as tumor factors, including pT4, rectal cancer, and poorly differentiated histology, in the multivariate analysis. On the other hand, the predictors for distant recurrence included perioperative factors, such as Clavien-Dindo score ≥ 3, and absence of adjuvant chemotherapy as well as tumor factors including pT stage, pN stage, and rectal cancer. The area under the receiver operating characteristic curve (AUC) for local recurrence in the IBL ratio was 0.745, which was higher than the AUCs for other recurrence patterns in the IBL ratio. Patients with a higher IBL ratio had a higher rate of early local recurrence within 2 years postoperatively (Wilcoxon test and p = 0.028).

conclusionReducing IBL and formulating perioperative strategies to prevent anastomotic leakage may help decrease the local recurrence rate and improve prognosis.

Indexed as

Blood Loss, SurgicalColorectal NeoplasmsNeoplasm Recurrence, LocalAdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedNeoplasm StagingRetrospective StudiesRisk Factorsanastomotic leakagecolorectal cancerintraoperative blood lossrecurrence pattern

Identifiers

PMID40088136
PMCPMC12058445

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.