ArticleNature communications2025
Neurotransmitters' white matter mapping unveils the neurochemical fingerprints of stroke.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Engineering localized injury: a 3D microfluidic platform approach for ex vivo tissue interrogation.Analytical and bioanalytical chemistry · 2026Article
- Spatially structured heterogeneity shapes large-scale cortical dynamics in a model of the human cortex.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Neurovariability as a signature of adaptive brain function.Brain structure & function · 2026Review
- Developmental changes of the white matter functional connectome.Molecular psychiatry · 2026Article
- Motor-related reorganization in left inferior frontal gyrus after subcortical stroke: neurochemical basis and response to targeted neuromodulation.BMC medicine · 2026Article
- Article
- Cortical white matter: no longer a silent partner.Frontiers in neuroanatomy · 2025Review
- Localization of brain networks activated by acupuncture at anatomically adjacent acupoints in healthy participants: neuroimaging evidence and implications for migraine and stroke.Frontiers in neuroscience · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Distinctive patterns of brain neurotransmission frame determinant circuits for behavior. Understanding the relationship between their damage and the cognitive impairment provoked by brain lesions could provide insights into the pathophysiology and therapeutics of disabling disorders, like stroke. Yet, the challenges of neurotransmitter circuits mapping in vivo have hampered this investigation. Here, we developed an MRI white matter atlas of neurotransmitter circuits and created a method to chart how stroke damages neurotransmitter systems, which distinguishes pre and postsynaptic disruption. Our model, trained and tested in two large stroke patient samples, identified eight clusters with different neurochemical patterns. The associations with patients' cognitive profiles were scarce, denoting that a particular cognitive deficit might have finer underlying neurochemical disturbances that are unfit to the granularity of our analyses. These findings depict stroke neurochemical diaschisis patterns, provide insights into stroke cognitive deficits and potential treatments, and open a new window for tailored neurotransmitter modulation.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.