Evidence mapPaperPMID 40089486Full record

ArticleNature communications2025

Midbrain ghrelin receptor signalling regulates binge drinking in a sex specific manner.

Amy J Pearl, Xavier J Maddern, Paulo Pinares-Garcia, Lauren T Ursich, Roberta G Anversa, Arnav Shesham, Robyn M Brown, Felicia M Reed, William J Giardino, Andrew J Lawrence and 1 more

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Sex differences in neural circuits driving binge-like drinking: a female-specific role for an amygdalo-striatal pathway.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  2. MDMA alters fear extinction, and reduces alcohol consumption in inbred alcohol preferring iP rats but not outbred Wistar rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  3. Sex-specific Serum Biomarker Associations with Antidepressant Treatment Outcomes in Depressive Disorders.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2026
    Article
  4. Negative feedback regulation of alcohol ingestion through the FGF21-PVH oxytocin-VTA dopamine system.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Amy J Pearl *Florey Institute of Neuroscience and Mental Health, Parkville, VIC, 3052, Australia.
Xavier J Maddern *Florey Institute of Neuroscience and Mental Health, Parkville, VIC, 3052, Australia.
Paulo Pinares-GarciaFlorey Institute of Neuroscience and Mental Health, Parkville, VIC, 3052, Australia.
Lauren T UrsichFlorey Institute of Neuroscience and Mental Health, Parkville, VIC, 3052, Australia.
Roberta G AnversaFlorey Institute of Neuroscience and Mental Health, Parkville, VIC, 3052, Australia.
Arnav SheshamFlorey Institute of Neuroscience and Mental Health, Parkville, VIC, 3052, Australia.
Robyn M BrownFlorey Institute of Neuroscience and Mental Health, Parkville, VIC, 3052, Australia.
Felicia M ReedBiomedicine Discovery Institute and Department of Physiology, Monash University, Clayton, VIC, Australia.
William J GiardinoDept. of Psychiatry and Behavioural Sciences, Stanford University School of Medicine, Stanford, CA, 94305-5453, USA.ORCID http://orcid.org/0000-0001-7474-7914
Andrew J LawrenceFlorey Institute of Neuroscience and Mental Health, Parkville, VIC, 3052, Australia.ORCID http://orcid.org/0000-0001-6836-727X
Leigh C WalkerFlorey Institute of Neuroscience and Mental Health, Parkville, VIC, 3052, Australia. leigh.walker@florey.edu.au.

Funding

Department of Health | National Health and Medical Research Council (NHMRC) 2002830Department of Health | National Health and Medical Research Council (NHMRC) 2008344
6 · The paper itself

Abstract

Risky drinking rates are rising, particularly in women, yet sex as a biological variable has only recently gained traction. The centrally projecting Edinger-Westphal (EWcp) nucleus has emerged as a key regulator of alcohol consumption. Here we found that EWcp

Indexed as

Binge DrinkingMesencephalonReceptors, GhrelinAnimalsFemaleGhrelinMaleMiceMice, Inbred C57BLNeuronsSex CharacteristicsSignal TransductionVentral Tegmental AreaGhrelinReceptors, Ghrelin

Identifiers

PMID40089486
PMCPMC11910522

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.