Evidence map›Paper›PMID 40089989›Full record

ArticleRevista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)2025

No changes in plasma brain-derived neurotrophic factor levels in treatment-resistant depression patients who underwent convulsive therapy.

Leonardo Afonso-Dos-Santos, Eric Cretaz, Helena Bellini, Adriana Munhoz Carneiro, José Gallucci-Neto, Leda Leme Talib, André Russowsky Brunoni

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Article in Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Leonardo Afonso-Dos-SantosServiço de Neuromodulação Interdisciplinar, Laboratório de Neurociências, Instituto de Psiquiatria, Hospital das Clinicas, Faculdade de Medicina, Universidade de São Paulo (USP), São Paulo, SP, Brazil. Serviço de Terapia Eletroconvulsiva, Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina, USP, São Paulo, SP, Brazil.
Eric CretazServiço de Neuromodulação Interdisciplinar, Laboratório de Neurociências, Instituto de Psiquiatria, Hospital das Clinicas, Faculdade de Medicina, Universidade de São Paulo (USP), São Paulo, SP, Brazil. Serviço de Terapia Eletroconvulsiva, Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina, USP, São Paulo, SP, Brazil.
Helena BelliniServiço de Neuromodulação Interdisciplinar, Laboratório de Neurociências, Instituto de Psiquiatria, Hospital das Clinicas, Faculdade de Medicina, Universidade de São Paulo (USP), São Paulo, SP, Brazil. Serviço de Terapia Eletroconvulsiva, Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina, USP, São Paulo, SP, Brazil.
Adriana Munhoz CarneiroServiço de Neuromodulação Interdisciplinar, Laboratório de Neurociências, Instituto de Psiquiatria, Hospital das Clinicas, Faculdade de Medicina, Universidade de São Paulo (USP), São Paulo, SP, Brazil. Serviço de Terapia Eletroconvulsiva, Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina, USP, São Paulo, SP, Brazil.
José Gallucci-NetoServiço de Terapia Eletroconvulsiva, Instituto de Psiquiatria, Hospital das Clinicas, Faculdade de Medicina, USP, São Paulo, SP, Brazil.
Leda Leme TalibServiço de Neuromodulação Interdisciplinar, Laboratório de Neurociências, Instituto de Psiquiatria, Hospital das Clinicas, Faculdade de Medicina, Universidade de São Paulo (USP), São Paulo, SP, Brazil.
André Russowsky BrunoniServiço de Neuromodulação Interdisciplinar, Laboratório de Neurociências, Instituto de Psiquiatria, Hospital das Clinicas, Faculdade de Medicina, Universidade de São Paulo (USP), São Paulo, SP, Brazil. Serviço de Terapia Eletroconvulsiva, Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina, USP, São Paulo, SP, Brazil.

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo 2019/06009-6São Paulo Research State Foundation 2019/06009-6
6 · The paper itself

Abstract

objectiveTo examine changes in plasma brain-derived neurotrophic factor (BDNF) levels in patients undergoing electroconvulsive therapy or magnetic seizure therapy, as well as any early or late variations in BDNF. Specific changes related to each technique were also evaluated.

methodsWe measured plasma BDNF before and throughout treatment in adult patients (18 to 65 years old) diagnosed with treatment-resistant depression who underwent convulsive therapy (electroconvulsive therapy or magnetic seizure therapy) in the ElectroMagnetic Convulsive therapy for DEpression (EMCODE) project.

resultsWe enrolled 31 participants (mean age = 38.4 years, SD = 11.88), of whom 14 (45.16%) underwent electroconvulsive therapy and 17 (54.84%) underwent magnetic seizure therapy. Notable improvements in depressive symptoms were observed in both groups, with no significant differences between them (p = 0.1046). However, no significant changes in plasma BDNF levels were observed for either technique pre- or post-treatment (mean difference = -93.01 pg/mL, 95%CI 545.88-359.86) or over time (coefficient = -67.95, standard error = 37.75, p = 0.072).

conclusionsThe findings suggest that no significant changes occurred in plasma BDNF levels following convulsive therapy, which challenges the notion that BDNF is a biomarker for treatment-resistant depression.

Indexed as

Brain-Derived Neurotrophic FactorDepressive Disorder, Treatment-ResistantElectroconvulsive TherapyMagnetic Field TherapyAdolescentAdultAgedBiomarkersFemaleHumansMaleMiddle AgedTime FactorsTreatment OutcomeYoung AdultBiomarkersBrain-Derived Neurotrophic Factorbrain-derived neurotrophic factorelectroconvulsive therapymagnetic seizure therapyneurophysiological biomarkersTreatment-resistant depression

Identifiers

PMID40089989
PMCPMC12815401

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.