Evidence map›Paper›PMID 40090194›Full record

ReviewFood chemistry2025

The emerging significance of furan fatty acids in food, nutrition, and potential therapeutic use.

Fei Chang, Pascal Rowart, Sonia R Salvatore, Oren Rom, Mark Mascal, Francisco J Schopfer

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Food chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Fei ChangDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
Pascal RowartDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
Sonia R SalvatoreDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
Oren RomDepartment of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, LA, 71103, USA; Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, LA, 71103, USA.
Mark MascalDepartment of Chemistry, University of California Davis, 1 Shields Avenue, Davis, CA 95616, USA.
Francisco J SchopferDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA. Electronic address: fjs2@pitt.edu.

Funding

Formation and metabolism of nitrated fatty acidsR01GM125944 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SCHOPFER, FRANCISCO JOSE · 2018 to 2025
$3.4M
Lipidated Amino Acids in Cardiometabolic DiseasesR01DK134011 · NIDDK · LOUISIANA STATE UNIV HSC SHREVEPORT · PI Oren Rom · 2022 to 2026
$2.1M
Dysregulated Oxalate Metabolism in Cardiometabolic DiseasesR01DK136685 · NIDDK · LOUISIANA STATE UNIV HSC SHREVEPORT · PI Oren Rom · 2023 to 2026
$1.7M
Mechanisms of glycine-based therapy for atherosclerosisR00HL150233 · NHLBI · LOUISIANA STATE UNIV HSC SHREVEPORT · PI ROM, OREN SHALOM · 2021 to 2023
$747k
Structurally engineered furan fatty acids for the treatment of dyslipidemia and cardiovascular diseaseR41HL167544 · NHLBI · FURANICA, INC. · PI SCHOPFER, FRANCISCO JOSE · 2023 to 2023
$299k
Structurally engineered N-acyl amino acids for the treatment of NASHR41DK137711 · NIDDK · FURANICA, INC. · PI SCHOPFER, FRANCISCO JOSE · 2023 to 2023
$294k
Furan fatty acids (FuFAs) as the active components of fish oils and omega-3 fatty acid productsR43AT009806 · NCCIH · FURANICA, INC. · PI CHANG, FEI · 2018 to 2018
$225k
NCCIH NIH HHS R43 AT009806NHLBI NIH HHS R00 HL150233NHLBI NIH HHS R41 HL167544NIDDK NIH HHS R01 DK134011NIDDK NIH HHS R01 DK136685NIDDK NIH HHS R41 DK137711NIGMS NIH HHS R01 GM125944
6 · The paper itself

Abstract

The emerging significance of furan fatty acids (FuFAs) is explored at the intersection of food, chemistry, nutrition, and therapeutics. FuFAs, with a distinctive furan ring incorporated into fatty acyl chains, are minor yet bioactive constituents of dietary lipids known for their unique chemical properties. This review examines FuFA biosynthesis in various organisms, highlighting their occurrence in food products. We also address the challenges of FuFA instability, which influence their availability and impact on food science. The chemical synthesis of FuFAs is reviewed, paving the way for future animal and human studies. FuFAs exhibit potent antioxidant and anti-inflammatory effects, with growing evidence of their role in metabolic health. Recent research suggests that FuFAs may extend benefits beyond omega-3 fatty acids in promoting cardiovascular and metabolic health. By consolidating current knowledge and identifying gaps, this review sets the stage for future research to harness the therapeutic potential of FuFAs.

Indexed as

Fatty AcidsFuransAnimalsAnti-Inflammatory AgentsAntioxidantsHumansAnti-Inflammatory AgentsAntioxidantsFatty AcidsFuransAntioxidantsChemical synthesisFish oilFuran fatty acidsInflammationMetabolismNutritionOmega-3 fatty acids

Identifiers

PMID40090194
PMCPMC12070325

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.