ArticleInternal medicine (Tokyo, Japan)2025
Role of a Bioelectrical Impedance Analysis in Predicting Anemia among Cardiovascular Disease Patients.
Article in Internal medicine (Tokyo, Japan), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
- Beyond the "Missing Link": The Association between Phase Angle and HbA1c.Internal medicine (Tokyo, Japan) · 2026Article
- Missing Link between Glycemic Control and Bioelectrical Impedance Analysis.Internal medicine (Tokyo, Japan) · 2026Article
- Complementary cardiac functional assessment using systolic time intervals and bioelectrical impedance analysis.Open heart · 2026Article
- Correlation between estimated plasma volume status and extracellular volume ratio determined by bioelectrical impedance analysis in cardiovascular disease patients.American heart journal plus : cardiology research and practice · 2026Article
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16 authors.
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Abstract
Objective Anemia frequently complicates cardiovascular disease (CVD) and is associated with high mortality rates. A bioelectrical impedance analysis (BIA) is a noninvasive method for measuring human body composition. A direct association between serum hemoglobin (Hb) levels and the extracellular water-to-total body water (ECW/TBW) ratio, as measured by a BIA in patients with diabetes, has been reported. However, the predictive value of the ECW/TBW ratio for detecting anemia in patients with CVD has not been fully elucidated. Methods We conducted a study involving consecutive patients admitted to our cardiology department from January 1, 2021, to December 31, 2022. A BIA was performed once during hospitalization for all patients, whenever possible. The correlation between the Hb level and ECW/TBW ratio was assessed. The predictive accuracy for anemia was evaluated using a receiver operating characteristic (ROC) curve analysis. Results The ECW/TBW ratio was significantly higher in the anemia group than in the non-anemia group [0.41 (0.40, 0.41) vs. 0.39 (0.38, 0.40), p<0.001]. The ECW/TBW ratio exhibited a significant negative correlation with Hb, with an R value of 0.57 and a p value of <0.01. However, this correlation coefficient decreased to 0.45 among subjects with B-type natriuretic peptide (BNP) levels ≥200 pg/mL. The area under the ROC curve (AUC) for the ECW/TBW ratio for detecting anemia was 0.83. However, its predictive performance decreased in patients with BNP levels exceeding 200 pg/mL, with an AUC of 0.71. Conclusion The BIA-derived ECW/TBW ratio is a valuable predictor of anemia in patients with CVD, provided BNP levels are not elevated.
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