Evidence mapPaperPMID 40091072Full record

ArticleMicrobiome2025

Short-term and long-term high-fat diet promote metabolic disorder through reprogramming mRNA m

Youhua Liu, Jiaqi Liu, Ruiti Ren, Zimeng Xin, Yaojun Luo, Yushi Chen, Chaoqun Huang, Yuxi Liu, Tongyudan Yang, Xinxia Wang

Abstract read
In one paragraph

Article in Microbiome, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Defined Microbiota Modulates Host Metabolome and Skeletal Adaptation to Diet-Induced Obesity.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  5. Article
  6. NBiomolecules · 2026
    Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Youhua Liu *College of Animal Sciences, Zhejiang University, Hangzhou, Zhejiang, China.
Jiaqi Liu *College of Animal Sciences, Zhejiang University, Hangzhou, Zhejiang, China.
Ruiti RenCollege of Animal Sciences, Zhejiang University, Hangzhou, Zhejiang, China.
Zimeng XinCollege of Animal Sciences, Zhejiang University, Hangzhou, Zhejiang, China.
Yaojun LuoCollege of Animal Sciences, Zhejiang University, Hangzhou, Zhejiang, China.
Yushi ChenCollege of Animal Sciences, Zhejiang University, Hangzhou, Zhejiang, China.
Chaoqun HuangCollege of Animal Sciences, Zhejiang University, Hangzhou, Zhejiang, China.
Yuxi LiuCollege of Animal Sciences, Zhejiang University, Hangzhou, Zhejiang, China.
Tongyudan YangCollege of Animal Sciences, Zhejiang University, Hangzhou, Zhejiang, China.
Xinxia WangCollege of Animal Sciences, Zhejiang University, Hangzhou, Zhejiang, China. xinxiawang@zju.edu.cn.

Funding

National Key Research and Development Program of China 2023YFD1301303National Natural Science Foundation of China 32330098Science and technology innovation leading talent project of Zhejiang Province 2022R52023
6 · The paper itself

Abstract

backgroundAlthough short-term high-fat diet (S-HFD) and long-term high-fat diet (L-HFD) induce metabolic disorder, the underlying epigenetic mechanism is still unclear.

resultsHere, we found that both 4 days of S-HFD and 10 weeks of L-HFD increased mRNA m

conclusionsTogether, this study reveals a novel mechanism that S-HFD and L-HFD induce metabolism disorder through gut microbiota-HGA-m

Indexed as

Adipose Tissue, WhiteDiet, High-FatGastrointestinal MicrobiomeMetabolic DiseasesRNA, MessengerAnimalsDNA Transposable ElementsEndogenous RetrovirusesEpigenesis, GeneticFecal Microbiota TransplantationHistone-Lysine N-MethyltransferaseLong Interspersed Nucleotide ElementsMaleMiceMice, Inbred C57BLDNA Transposable ElementsHistone-Lysine N-MethyltransferaseRNA, MessengerEHMT2ERVsGut microbiotaHigh-fat dietHomogentisic acidLINEsm6AMetabolic disorder

Identifiers

PMID40091072
PMCPMC11912683

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.