Evidence map›Paper›PMID 40092095›Full record

ArticleAmerican journal of translational research2025

Novel approaches to improve systemic bioavailability of curcumin using probiotics for rotenone-induced Parkinson's disease in rodents.

Arun Soni, Adarsh Patel, Sanjeev Acharya, Alkesh Patel, Umang Shah, Swayamprakash Patel, Nilay Solanki, Mehul Patel

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PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Gut Microbiome as a Source of Probiotic Drugs for Parkinson's Disease.International journal of molecular sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Arun SoniRamanbhai Patel College of Pharmacy, Charotar University of Science and Technology, CHARUSAT Campus Changa, Anand, Gujarat 388421, India.
Adarsh PatelDepartment of Pharmacology, SSR College of Pharmacy Sayli-Silvassa Road, Union Territory of Dadra and Nagar Haveli and Daman Diu, Sayli, Silvassa 396230, India.
Sanjeev AcharyaDepartment of Pharmacology, SSR College of Pharmacy Sayli-Silvassa Road, Union Territory of Dadra and Nagar Haveli and Daman Diu, Sayli, Silvassa 396230, India.
Alkesh PatelRamanbhai Patel College of Pharmacy, Charotar University of Science and Technology, CHARUSAT Campus Changa, Anand, Gujarat 388421, India.
Umang ShahRamanbhai Patel College of Pharmacy, Charotar University of Science and Technology, CHARUSAT Campus Changa, Anand, Gujarat 388421, India.
Swayamprakash PatelRamanbhai Patel College of Pharmacy, Charotar University of Science and Technology, CHARUSAT Campus Changa, Anand, Gujarat 388421, India.
Nilay SolankiRamanbhai Patel College of Pharmacy, Charotar University of Science and Technology, CHARUSAT Campus Changa, Anand, Gujarat 388421, India.
Mehul PatelRamanbhai Patel College of Pharmacy, Charotar University of Science and Technology, CHARUSAT Campus Changa, Anand, Gujarat 388421, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimThe prevalence of Parkinson's Disease (PD) is high, and treatment is not optimal to date. Curcumin possesses neuroprotective effects. Nevertheless, oral use is incommodious due to its poor bioavailability. Numerous attempts have been made to increase its systemic bioavailability. Among these, an effective way to increase the bioavailability of curcumin is by combining it with probiotics to target the glucuronidation reaction. The present study focuses on the bio-enhancement of curcumin using probiotics in animal models of PD by alleviating oxidative stress and ameliorating dopamine levels. MATERIALS AND

methodsForty-two male rats were used for the study. Twelve animals were used for a bio-availability study in which curcumin was administered orally alone and concomitantly with a probiotic ( RESULTS AND

conclusionsThe bioavailability study revealed a significant (

Indexed as

curcuminneurotherapeuticoxidative stressParkinson’s diseaserotenoneβ-glucuronidase activity

Identifiers

PMID40092095
PMCPMC11909508

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.