ArticleOpen veterinary journal2025
Implantation of porcine amniotic epithelial cells model for myocardial infarction combined with cardiomyocyte therapy of pigs (
Article in Open veterinary journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
Background: Myocardial infarction (MI) is the most common heart disorder in patients with cardiovascular disease. Obstruction of blood flow to the heart causes ischemia and results in heart pump failure. Aim: This study aims to evaluate the effects of porcine amniotic epithelial cell (pAEC)-based stem cell therapy alone and in combination with cardiomyocytes to understand its potential benefits in MI treatment. Methods: In this study, we conducted MI therapy using pluripotent stem cells derived from the amnion (AEC) implanted into the infarcted heart. Nine domestic pigs ( Results: Single pAEC stem cell therapy and its combination with cardiomyocytes in MI lesions demonstrated improvements in VTI, particularly renal artery, mitral, and tricuspid valve compared to untreated infarction (placebo). Notably, single pAEC therapy significantly improved more than combining them with cardiomyocytes. Conclusion: Treatment with AEC stem cells alone resulted in more significant improvements in heart valve function and large blood vessels compared to combining AEC with cardiomyocytes. This study allowed us to understand better the effects of stem cell therapy on blood hemodynamics and biomarker parameters of heart injury.
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