Evidence map›Paper›PMID 40093093›Full record

ArticlebioRxiv : the preprint server for biology2025

Structural basis of ClC-3 inhibition by TMEM9 and PI(3,5)P

Marina Schrecker, Yeeun Son, Rosa Planells-Cases, Sumanta Kar, Viktoriia Vorobeva, Uwe Schulte, Bernd Fakler, Thomas J Jentsch, Richard K Hite

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Marina SchreckerStructural Biology Program, Memorial Sloan Kettering Cancer Center; New York, NY, USA.
Yeeun SonStructural Biology Program, Memorial Sloan Kettering Cancer Center; New York, NY, USA.
Rosa Planells-CasesLeibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP); Berlin, Germany.
Sumanta KarLeibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP); Berlin, Germany.
Viktoriia VorobevaLeibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP); Berlin, Germany.
Uwe SchulteInstitute of Physiology, Faculty of Medicine, University of Freiburg; Freiburg, Germany.
Bernd FaklerInstitute of Physiology, Faculty of Medicine, University of Freiburg; Freiburg, Germany.
Thomas J JentschLeibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP); Berlin, Germany.
Richard K HiteStructural Biology Program, Memorial Sloan Kettering Cancer Center; New York, NY, USA.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Michael Jason de la Cruz · 1985 to 2026
$347.4M
Mechanisms of lysosomal ion transport proteins involved in pH homeostasisR01GM141553 · NIGMS · SLOAN-KETTERING INST CAN RESEARCH · PI HITE, RICHARD KEVIN · 2022 to 2025
$1.8M
NCI NIH HHS P30 CA008748NIGMS NIH HHS R01 GM141553
6 · The paper itself

Abstract

The trafficking and activity of endosomes relies on the exchange of chloride ions and protons by members of the CLC family of chloride channels and transporters, whose mutations are associated with numerous diseases. Despite their critical roles, the mechanisms by which CLC transporters are regulated are poorly understood. Here, we show that two related accessory β-subunits, TMEM9 and TMEM9B, directly interact with ClC-3, -4 and -5. Cryo-EM structures reveal that TMEM9 inhibits ClC-3 by sealing the cytosolic entrance to the Cl

Identifiers

PMID40093093
PMCPMC11908120

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.