ArticlebioRxiv : the preprint server for biology2025
The KASH protein UNC-83 differentially regulates kinesin-1 activity to control developmental stage-specific nuclear migration.
Selin Gümüşderelioğlu, Natalie Sahabandu, Daniel Elnatan, Ellen F Gregory, Kyoko Chiba, Shinsuke Niwa, G W Gant Luxton, Richard J McKenney, Daniel A Starr
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
9 authors.
Selin GümüşderelioğluDepartment of Molecular and Cellular Biology, University of California, 1 Shields Ave, Davis, CA 95616, United States.
Natalie SahabanduDepartment of Molecular and Cellular Biology, University of California, 1 Shields Ave, Davis, CA 95616, United States.
Daniel ElnatanDepartment of Molecular and Cellular Biology, University of California, 1 Shields Ave, Davis, CA 95616, United States.
Ellen F GregoryDepartment of Molecular and Cellular Biology, University of California, 1 Shields Ave, Davis, CA 95616, United States.
Kyoko ChibaFrontier Research Institute for Interdisciplinary Sciences, Tohoku University, Miyagi, 6-3 Aramaki Aoba, Aoba-ku, Sendai 980-0845, Japan.ORCID 0000-0001-6919-2782 Shinsuke NiwaFrontier Research Institute for Interdisciplinary Sciences, Tohoku University, Miyagi, 6-3 Aramaki Aoba, Aoba-ku, Sendai 980-0845, Japan.ORCID 0000-0002-8367-9228 G W Gant LuxtonDepartment of Molecular and Cellular Biology, University of California, 1 Shields Ave, Davis, CA 95616, United States.ORCID 0000-0002-6180-8906 Richard J McKenneyDepartment of Molecular and Cellular Biology, University of California, 1 Shields Ave, Davis, CA 95616, United States.
Daniel A StarrDepartment of Molecular and Cellular Biology, University of California, 1 Shields Ave, Davis, CA 95616, United States.
Funding
Coordination of molecular motor activity in intracellular transport and assembly of cytoskeletal architecture.R35GM124889 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Richard James McKenney · 2017 to 2026
$4.3MMechanisms of Nuclear MigrationR35GM134859 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI DANIEL A STARR · 2020 to 2026
$2.8MNIGMS NIH HHS R35 GM124889NIGMS NIH HHS R35 GM134859
6 · The paper itselfAbstract
Nuclear migration plays a fundamental role in development, requiring precise spatiotemporal control of bidirectional movement through dynein and kinesin motors. Here, we uncover a mechanism for developmental regulation of nuclear migration directionality. The nuclear envelope KASH protein UNC-83 in
Indexed as
C. elegansdyneinKASH proteinskinesin-1LINC complexnuclear migration
Identifiers
PMID40093101
PMCPMC11908248
What Socratic holds
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