Evidence map›Paper›PMID 40093121›Full record

ArticlebioRxiv : the preprint server for biology2025

TOR and heat shock response pathways regulate peroxisome biogenesis during proteotoxic stress.

Nandini Shukla, Maxwell L Neal, Jean-Claude Farré, Fred D Mast, Linh Truong, Theresa Simon, Leslie R Miller, John D Aitchison, Suresh Subramani

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Nandini ShuklaDepartment of Molecular Biology, School of Biological Sciences, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0003-2750-229X
Maxwell L NealCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA.ORCID 0000-0002-2390-6572
Jean-Claude FarréDepartment of Molecular Biology, School of Biological Sciences, University of California, San Diego, La Jolla, CA, USA.
Fred D MastCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA.ORCID 0000-0002-2177-6647
Linh TruongDepartment of Molecular Biology, School of Biological Sciences, University of California, San Diego, La Jolla, CA, USA.
Theresa SimonDepartment of Molecular Biology, School of Biological Sciences, University of California, San Diego, La Jolla, CA, USA.
Leslie R MillerCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA.
John D AitchisonCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA.
Suresh SubramaniDepartment of Molecular Biology, School of Biological Sciences, University of California, San Diego, La Jolla, CA, USA.

Funding

TARGETING OF PROTEINS INTO PEROXISOMESR01DK041737 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI AITCHISON, JOHN D., SUBRAMANI, SURESH · 1990 to 2025
$8.4M
NIDDK NIH HHS R01 DK041737
6 · The paper itself

Abstract

Peroxisomes are versatile organelles mediating energy homeostasis and redox balance. While peroxisome dysfunction is linked to numerous diseases, the molecular mechanisms and signaling pathways regulating peroxisomes during cellular stress remain elusive. Using yeast, we show that perturbations disrupting protein homeostasis including loss of ER or cytosolic chaperone function, impairments in ER protein translocation, blocking ER N-glycosylation, or reductive stress, cause peroxisome proliferation. This proliferation is driven by increased

Identifiers

PMID40093121
PMCPMC11908190

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.