Evidence map›Paper›PMID 40093207›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Protective targets of PfSPZ vaccines identified from whole-genome sieve analysis of isolates from malaria vaccine efficacy trials in West Africa.

Ankit Dwivedi, Ryan J Scalsky, David G Harris, Thomas C Stabler, Biraj Shrestha, Sudhaunshu Joshi, Chakshu Gandhi, James B Munro, Olukemi O Ifeonu, Alphonse Ouedraogo and 13 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Ankit DwivediInstitute for Genome Sciences, University of Maryland School of Medicine; Baltimore, MD 21201, USA.
Ryan J ScalskyInstitute for Genome Sciences, University of Maryland School of Medicine; Baltimore, MD 21201, USA.
David G HarrisDepartment of Computer Science, University of Maryland College Park; College Park, MD 20742, USA.
Thomas C StablerSwiss Tropical Public Health Institute; 4123 Allschwil, Switzerland.
Biraj ShresthaCenter for Vaccine Development and Global Health, University of Maryland School of Medicine; Baltimore, MD 21201, USA.
Sudhaunshu JoshiCenter for Vaccine Development and Global Health, University of Maryland School of Medicine; Baltimore, MD 21201, USA.
Chakshu GandhiInstitute for Genome Sciences, University of Maryland School of Medicine; Baltimore, MD 21201, USA.
James B MunroInstitute for Genome Sciences, University of Maryland School of Medicine; Baltimore, MD 21201, USA.
Olukemi O IfeonuInstitute for Genome Sciences, University of Maryland School of Medicine; Baltimore, MD 21201, USA.
Alphonse OuedraogoGroupe de Recherche Action en Santé; Ouagadougou, Burkina Faso.
Alfred B TionoGroupe de Recherche Action en Santé; Ouagadougou, Burkina Faso.
Drissa CoulibalyMalaria Research and Training Center, University of Sciences, Techniques and Technologies, Bamako; Bamako, Mali.ORCID 0000-0002-7412-0940
Amed OuattaraCenter for Vaccine Development and Global Health, University of Maryland School of Medicine; Baltimore, MD 21201, USA.
Thomas L RichieSanaria Inc.; Rockville, MD 20850, USA.
B Kim Lee SimSanaria Inc.; Rockville, MD 20850, USA.
Christopher V PloweCenter for Vaccine Development and Global Health, University of Maryland School of Medicine; Baltimore, MD 21201, USA.
Kirsten E LykeCenter for Vaccine Development and Global Health, University of Maryland School of Medicine; Baltimore, MD 21201, USA.
Shannon Takala-HarrisonCenter for Vaccine Development and Global Health, University of Maryland School of Medicine; Baltimore, MD 21201, USA.
Stephen L HoffmanSanaria Inc.; Rockville, MD 20850, USA.
Mahamadou A TheraMalaria Research and Training Center, University of Sciences, Techniques and Technologies, Bamako; Bamako, Mali.
Sodiomon B SirimaGroupe de Recherche Action en Santé; Ouagadougou, Burkina Faso.
Matthew B LaurensCenter for Vaccine Development and Global Health, University of Maryland School of Medicine; Baltimore, MD 21201, USA.ORCID 0000-0003-3874-581X
Joana C SilvaInstitute for Genome Sciences, University of Maryland School of Medicine; Baltimore, MD 21201, USA.ORCID 0000-0001-6502-7026

Funding

Genome-wide sieve analysis and immunological validation to identify targets of protective efficacy in field trials of a whole-organism malaria vaccineR01AI141900 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI CARNEIRO DA SILVA, JOANA · 2019 to 2023
$3.9M
Safety and efficacy of PfSPZ malaria vaccine in malaria-exposed adultsU01AI112367 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI LAURENS, MATTHEW BRENT · 2015 to 2018
$2.8M
NIAID NIH HHS HHSN272201300022CNIAID NIH HHS HHSN272201300022INIAID NIH HHS R01 AI141900NIAID NIH HHS U01 AI112367
6 · The paper itself

Abstract

Identification of antigens targeted by a protective response is a central quest in malaria vaccinology. Whole-genome sieve analysis (SA

Identifiers

PMID40093207
PMCPMC11908318

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.