Evidence map›Paper›PMID 40093571›Full record

ArticleCancer management and research2025

Prognostic Value of Ferroptosis-Immunity-Related Signature Genes in Cervical Cancer Radiotherapy Resistance and Risk Modeling.

Xianzhen Zhang, Aihua Li, Wanqi Zhu, Qiufen Guo, Qian Wu, Hong Zhao, Yunbei Yu, Peng Xie, Xiaolin Li

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PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer management and research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xianzhen ZhangDepartment of Oncology, Liaocheng People's Hospital, Liaocheng, Shandong, 252000, People's Republic of China.
Aihua LiCheeloo College of Medicine, Shandong University, Jinan, Shandong, 250000, People's Republic of China.
Wanqi ZhuDepartment of Radiation Oncology, Shandong First Medical University Affiliated Cancer Hospital (Shandong Academy of Medical Sciences), Jinan, Shandong, 250117, People's Republic of China.
Qiufen GuoDepartment of Gynecological Tumor Radiation Oncology, Shandong First Medical University Affiliated Cancer Hospital (Shandong Academy of Medical Sciences), Jinan, Shandong, 250117, People's Republic of China.
Qian WuDepartment of Gynecological Tumor Radiation Oncology, Shandong First Medical University Affiliated Cancer Hospital (Shandong Academy of Medical Sciences), Jinan, Shandong, 250117, People's Republic of China.
Hong ZhaoDepartment of Radiation Oncology, Shandong First Medical University Affiliated Cancer Hospital (Shandong Academy of Medical Sciences), Jinan, Shandong, 250117, People's Republic of China.
Yunbei YuDepartment of Oncology, Liaocheng People's Hospital, Liaocheng, Shandong, 252000, People's Republic of China.
Peng XieDepartment of Gynecological Tumor Radiation Oncology, Shandong First Medical University Affiliated Cancer Hospital (Shandong Academy of Medical Sciences), Jinan, Shandong, 250117, People's Republic of China.ORCID 0000-0001-8647-2882
Xiaolin LiDepartment of Radiation Oncology, Shandong First Medical University Affiliated Cancer Hospital (Shandong Academy of Medical Sciences), Jinan, Shandong, 250117, People's Republic of China.ORCID 0000-0001-8418-6233

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The aim of this study was to clarify the genome of ferroptosis in the genes involved in radiotherapy resistance and regulation of tumor immune microenvironment by multigene analysis of cervical cancer (CC) patients. Methods: Different radiation sensitivity samples from CC patients were collected for RNA sequencing. Differentially expressed genes (DEGs) between the RNA dataset and the GSE9750 dataset were considered as radiotherapy-DEGs. The intersection genes of radiotherapy-DEGs with ferroptosis-related genes (FRGs) and the intersection genes of radiotherapy-DEGs with immune-related genes (IRGs) were labeled as FRGs-IRGs-DEGs (FIGs). A risk model was established by prognostic genes selected from FIGs by univariate Cox analysis and least absolute shrinkage and selection operator (LASSO) analysis. The results were further validated using samples from CC tissue samples. Results: The 329 DEGs related to CC radiotherapy were identified. LSAAO analysis was utilized to identify five prognostic genes ( Discussion: A novel prognostic model related to ferroptosis and immune microenvironment in CC radiotherapy was developed and validated, providing valuable guidance for personalized anti-cancer therapy.

Indexed as

cervical cancerferroptosisradiotherapyrisk modelsingle-cell RNA-seq analysis

Identifiers

PMID40093571
PMCPMC11910962

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.