Evidence map›Paper›PMID 40094068›Full record

ArticleGlobal heart2025

Sex Differences in Acute Coronary Syndromes: A Scoping Review Across the Care Continuum.

Anna Marzà-Florensa, Pauline Kiss, Dina Mohamed Youssef, Sara Jalali-Farahani, Fernando Lanas, Mariachiara di Cesare, José Ramón González Juanatey, Sean Taylor, Alicia Uijl, Diederick E Grobbee and 3 more

Abstract readScoping Review
In one paragraph

Article in Global heart, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Heart failure care in low-middle income countries: Time for incorporating gender-specific guidelines?International journal of cardiology. Cardiovascular risk and prevention · 2025
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Anna Marzà-FlorensaGlobal Public Health and Bioethics, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.ORCID 0000-0003-0338-4292
Pauline KissGlobal Public Health and Bioethics, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.ORCID 0000-0002-3654-4881
Dina Mohamed YoussefGlobal Public Health and Bioethics, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.ORCID 0000-0002-7623-5733
Sara Jalali-FarahaniInstitute of Public Health & Wellbeing, University of Essex, United Kingdom.ORCID 0000-0003-4905-0191
Fernando LanasUniversidad de La Frontera, Chile.ORCID 0000-0003-3595-9759
Mariachiara di CesareInstitute of Public Health & Wellbeing, University of Essex, United Kingdom.ORCID 0000-0002-3934-3364
José Ramón González JuanateyUniversity Hospital, Santiago de Compostela, Spain.ORCID 0000-0001-9681-3388
Sean TaylorWorld Heart Federation, Geneva, Switzerland.ORCID 0000-0002-5031-3588
Alicia UijlGlobal Public Health and Bioethics, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.ORCID 0000-0003-2835-7741
Diederick E GrobbeeGlobal Public Health and Bioethics, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.ORCID 0000-0003-4472-4468
Sarah Des RosiersThe Novartis Foundation, Basel, Switzerland.
Pablo PerelWorld Heart Federation, Geneva, Switzerland.ORCID 0000-0002-2342-301X
Sanne A E PetersGlobal Public Health and Bioethics, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.ORCID 0000-0003-0346-5412

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Optimal diagnosis and management of acute coronary syndrome (ACS) is essential to improve clinical outcomes and prognosis. Sex disparities in ACS care have been reported in the literature, but evidence gaps remain. This review aims to map and to summarize the global evidence on sex differences in the provision of care across the ACS continuum. Methods: A systematic literature search was conducted in Pubmed, EMBASE, and the World Health Organization Global Index Medicus. The search was restricted to original research articles published between January 1, 2013, and August 30 Results: Of the 15,033 identified articles, 446 articles (median percentage of women per study: 29%), reporting on 1,483 outcomes, were included. Most studies were conducted in high-income regions (65%). Studies reported on pre-hospital care (8%), diagnosis (9%), treatment (45%), discharge (14%) and events (24%). For 45% of outcomes, results favored men, 5% favored women, and 50% showed mixed results or no sex difference. ACS care aspects with the largest sex differences were pre-hospital care (58% of the outcomes favored men vs 7% favored women) and diagnosis (70% favored men vs 2% favored women). Conclusion: Studies on sex differences in ACS mainly come from high-income regions. Sex differences in ACS management are widely reported and mainly unfavorable to women, especially in the early phases of pre-hospital care and diagnosis.

Indexed as

Acute Coronary SyndromeContinuity of Patient CareHealthcare DisparitiesFemaleHumansMaleSex Factorsacute coronary syndromecardiovascular diseasediagnosisglobal healthpre-hospital caresex differences

Identifiers

PMID40094068
PMCPMC11908429

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.