ArticleAging clinical and experimental research2025
Correlation of alternative healthy eating index with risk of frailty among metabolic syndrome individuals: a cross-sectional study.
Article in Aging clinical and experimental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundMounting evidence identifies diet quality as a frailty modifying factor. Individuals suffering from metabolic syndrome (MetS) are more likely to be affected by frailty. Therefore, our research sought to explore the relationship of Alternative Healthy Eating Index (AHEI) with frailty risk among patients with MetS.
methodsNational Health and Nutrition Examination Survey (NHANES) data from 2005 to 2018 were gathered. Frailty Index (FI) was utilized for assessment of frailty status. Weighted multivariate logistic regression model was adopted for investigating the association of AHEI with frailty among patients with MetS. Subgroup analysis, interaction test and restricted cubic spline (RCS) test were also performed in this study.
resultsWhen the covariates considered were entirely adjusted for, higher AHEI scores exhibited significant association with reduced frailty risk (OR = 0.99,95%CI = 0.981-0.998, P = 0.022). Relative to the frailty risk among participants belonging to the lowest AHEI quartile(Q1), that of individuals in the highest AHEI quartile(Q4) decreased by 32% (OR = 0.68, 95% CI = 0.51-0.92, P = 0.01). Additionally, the negative association of AHEI with frailty persisted for all subgroup analyses, which also indicates the reliability of the relationship.
conclusionFor patients with MetS, higher AHEI scores reduce the risk of developing frailty. This investigation provides valuable knowledge that could be utilized for treating MetS patients clinically and guiding healthy eating program development.
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